Studies on the Mechanisms of Leukocyte Adhesion to Cellulose Acetate Beads: An In Vitro Model to Assess the Efficacy of Cellulose Acetate Carrier‐based Granulocyte and Monocyte Adsorptive Apheresis

Hiraishi, Katsuya; Takeda, Yuji; Shiobara, Noriyuki; Shibusawa, H.; Jimma, Fumie; Kashiwagi, Nobuhito; Saniabadi, Abby R.; Adachi, Masakazu

doi:10.1046/j.1526-0968.2003.00049.x

Cited by 108 publications

(130 citation statements)

References 26 publications

(22 reference statements)

Supporting

Mentioning

126

Contrasting

Unclassified

Order By: Relevance

“…Adacolumn R is a therapeutic extracorporeal device, which selectively adsorbs granulocytes and monocytes from peripheral blood. The selective adsorption is thought to be mediated by interactions of complement and Fc receptors on the granulocytes and monocytes, whereas complement factor and immunoglobulins adhere onto the surface of G-1 beads by ligand-receptor interactions [3] . Granulocytes and monocytes are believed to play a significant role in these and other autoimmune inflammatory diseases because of their capability to release a variety of mediators including active oxygen species and inflammator y cytokines, such as tumor necrosis factor-α (TNF-α) and interleukin β (IL1-β) [4,5] .…”

Section: Introductionmentioning

confidence: 99%

Regulatory T cells in patients with inflammatory bowel diseases treated with adacolumn granulocytapheresis

Cuadrado¹,

Alonso²,

Juan³

et al. 2008

WJG

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Regulatory T cells in patients with inflammatory bowel diseases treated with adacolumn granulocytapheresis

Cuadrado¹,

Alonso²,

Juan³

et al. 2008

WJG

View full text Add to dashboard Cite

show abstract

“…Patients with immune dysfunction may have immune complexes (IC) in their plasma (7,51,52). Cellulose acetate adsorbs immunoglobulin G (IgG) and IC from the plasma (52,53). Upon adsorption, the binding sites on IgG and IC become available for the Fc receptors (Fc Rs) on myelocytes (7,(51)(52)(53).…”

Section: Therapeutic Leucocytapheresis In Ulcerative Colitis -Logics mentioning

confidence: 99%

“…Cellulose acetate adsorbs immunoglobulin G (IgG) and IC from the plasma (52,53). Upon adsorption, the binding sites on IgG and IC become available for the Fc receptors (Fc Rs) on myelocytes (7,(51)(52)(53). Further, cellulose acetate with adsorbed IgG and IC generates complement activation fragments including C3a and C5a (7,52,53).…”

Section: Therapeutic Leucocytapheresis In Ulcerative Colitis -Logics mentioning

confidence: 99%

“…Upon adsorption, the binding sites on IgG and IC become available for the Fc receptors (Fc Rs) on myelocytes (7,(51)(52)(53). Further, cellulose acetate with adsorbed IgG and IC generates complement activation fragments including C3a and C5a (7,52,53). The opsonins C3b/C3bi and others derived from the activation fragments also adsorb onto the carriers and serve as binding sites for the leucocyte complement receptors, CR1, CR2, CR3 (Mac-1, CD11b/CD18).…”

Section: Therapeutic Leucocytapheresis In Ulcerative Colitis -Logics mentioning

confidence: 99%

“…The opsonins C3b/C3bi and others derived from the activation fragments also adsorb onto the carriers and serve as binding sites for the leucocyte complement receptors, CR1, CR2, CR3 (Mac-1, CD11b/CD18). Hence, leucocyte adsorption to the GMA carriers in the Adacolumn is governed by the opsonins, Fc Rs and the leucocytes complement receptors (7,53). The expressions of these sets of receptors are common features of myeloid linage leucocytes.…”

Section: Therapeutic Leucocytapheresis In Ulcerative Colitis -Logics mentioning

confidence: 99%

See 2 more Smart Citations

The Diagnostic Value of Colonoscopy in Understanding Inflammatory Mucosal Damage in Patients with Ulcerative Colitis and Predicting Clinical Response to Adsorptive Leucocytapheresis as a Non-Pharmacologic Treatment Intervention

Saniabadi¹,

Suzuki²

2011

Endoscopic Procedures in Colon and Rectum

View full text Add to dashboard Cite

Endoscopic Procedures in Colon and Rectum 82by diverse environmental factors (2). From here on, we shall focus only on UC. The severity of UC is often presented by clinical activity index (CAI). Another, but complementary parameter is endoscopic activity index, not used in this chapter. Colonoscope, the gastroenterologist's eye and arms in modern timesColonoscopy is a revolutionary development in gastroenterology, now days like both arm and eyes for specialist gastroenterologists that can reach the inside of the large and distal segment of the small intestine. Introduced in the late 1960s (3), the term, colonoscopy refers to the endoscopic examination of the bowel with a charge-coupled device (CCD) camera or a fiber optic camera on a flexible tube passed through the rectal opening. As the name implies, colonoscopy allows a visual diagnosis of intestinal wall lesions like inflammation, ulceration, polyps and provides the opportunity for biopsy or removal of suspected cancerous lesions. Colonoscopy can remove polyps as small as one millimetre or less. Once polyps are removed, they can be studied with the aid of a microscope to determine if they are precancerous or not. Retrograde colonoscopy of the entire colon, and endoscopic excision of polyps from anywhere in the colon, began in 1969 (4). Momentous advances have occurred over the past two decades, and the two procedures are now widely accepted and practiced. Development and perfection of the methodology were, at first, fraught with many difficulties, both procedural and technical, which had to be overcome. Significant opposition was engendered in the early years by some who claimed that the methods were both unnecessary and unduly dangerous. Time has proven otherwise. Progress came about as the result of a steady stream of publications from a number of centres documenting the successful and safe application of the methodology. More advanced versions include virtual colonoscopy, which uses 2D and 3D imagery reconstructed from computed tomography (CT) scans or from nuclear magnetic resonance (MR) scans, is also possible, as a totally non-invasive medical test. However, unlike standard colonoscopy, virtual colonoscopy does not allow for therapeutic maneuvers such as polyp/tumour removal or biopsy nor visualization of lesions smaller than 5 millimeters. If a growth or polyp is detected by using CT colonography, a standard colonoscopy would still need to be performed. Further, colonoscopy is similar to, but not the same as, sigmoidoscopy, the difference being related to which parts of the colon each can examine. A colonoscopy allows an examination of the entire colon (measuring more than 1.5m in length). A sigmoidoscopy allows an examination of only the final 60cm of the colon. A sigmoidoscopy is often used as a screening procedure for a full colonoscopy to be followed in many instances in conjunction with a faecal occult blood test, which can detect the formation of cancerous cells throughout the colon. At other times, a sigmoidoscopy is preferred to a full colonos...

show abstract

Kill the Messenger of Bad News?

Dias

2004

J. pediatr. gastroenterol. nutr.

View full text Add to dashboard Cite

Studies on the Mechanisms of Leukocyte Adhesion to Cellulose Acetate Beads: An In Vitro Model to Assess the Efficacy of Cellulose Acetate Carrier‐based Granulocyte and Monocyte Adsorptive Apheresis

Cited by 108 publications

References 26 publications

Regulatory T cells in patients with inflammatory bowel diseases treated with adacolumn granulocytapheresis

Regulatory T cells in patients with inflammatory bowel diseases treated with adacolumn granulocytapheresis

The Diagnostic Value of Colonoscopy in Understanding Inflammatory Mucosal Damage in Patients with Ulcerative Colitis and Predicting Clinical Response to Adsorptive Leucocytapheresis as a Non-Pharmacologic Treatment Intervention

Kill the Messenger of Bad News?

Contact Info

Product

Resources

About