Studies on the Living Cornea In Vitro

Ionic Components of Electric Current at Rat Corneal Wounds

“…The corneas of different species have different mechanisms of ion transport. In rabbits, for example, sodium is transported inward, which is surprising since this does not seem to favor water removal from the stroma [53], [54].…”

Ionic Components of Electric Current at Rat Corneal Wounds

“…The corneas of different species have different mechanisms of ion transport. In rabbits, for example, sodium is transported inward, which is surprising since this does not seem to favor water removal from the stroma [53], [54].…”

Stable Gastric Pentadecapeptide BPC 157—Possible Novel Therapy of Glaucoma and Other Ocular Conditions

“…Namely, maintained (recovered) corneal transparency (and thereby maintenance of visual function) implies that the therapy may successfully recover the integrity of all its components (i.e., epithelium, stroma, and endothelium) [ 181 , 182 ]. Moreover, in general terms, the prevented/reversed corneal swelling should include the recovered metabolic and functioning as diffusion barriers to the fluid (tears or aqueous humor) of the epithelium and endothelium, in particular [ 182 , 183 , 184 , 185 , 186 ]. This should be achieved given the major role of maintaining corneal hydration; the endothelium barrier and pump functions should both be recovered to achieve the recovery of corneal swelling and opacity [ 182 , 183 , 184 , 185 , 186 ].…”

“…Moreover, in general terms, the prevented/reversed corneal swelling should include the recovered metabolic and functioning as diffusion barriers to the fluid (tears or aqueous humor) of the epithelium and endothelium, in particular [ 182 , 183 , 184 , 185 , 186 ]. This should be achieved given the major role of maintaining corneal hydration; the endothelium barrier and pump functions should both be recovered to achieve the recovery of corneal swelling and opacity [ 182 , 183 , 184 , 185 , 186 ]. Noteworthy, BPC 157 therapy commences after cornea perforation.…”

Electrical signaling in control of ocular cell behaviors

“…To remain transparent, corneal water balance/hydration level (deturgesence) must be regulated within a specific physiological range (Donn et al, 1959; Klyce, 1975, 1977; Klyce and Crosson, 1985; Klyce and Wong, 1977; Maurice, 1951, 1967, 1972; Reinach et al, 2008b). Transport of ions coupled with water transport regulate the osmolarity balance between the corneal stroma, the anterior chamber, and the tear fluid, thus regulating deturgesence (Edelhauser, 2006).…”

Ionic Components of Electric Current at Rat Corneal Wounds

“…The corneas of different species have different mechanisms of ion transport. In rabbits, for example, sodium is transported inward, which is surprising since this does not seem to favor water removal from the stroma [53], [54].…”

Stable Gastric Pentadecapeptide BPC 157—Possible Novel Therapy of Glaucoma and Other Ocular Conditions

“…Namely, maintained (recovered) corneal transparency (and thereby maintenance of visual function) implies that the therapy may successfully recover the integrity of all its components (i.e., epithelium, stroma, and endothelium) [ 181 , 182 ]. Moreover, in general terms, the prevented/reversed corneal swelling should include the recovered metabolic and functioning as diffusion barriers to the fluid (tears or aqueous humor) of the epithelium and endothelium, in particular [ 182 , 183 , 184 , 185 , 186 ]. This should be achieved given the major role of maintaining corneal hydration; the endothelium barrier and pump functions should both be recovered to achieve the recovery of corneal swelling and opacity [ 182 , 183 , 184 , 185 , 186 ].…”

“…Moreover, in general terms, the prevented/reversed corneal swelling should include the recovered metabolic and functioning as diffusion barriers to the fluid (tears or aqueous humor) of the epithelium and endothelium, in particular [ 182 , 183 , 184 , 185 , 186 ]. This should be achieved given the major role of maintaining corneal hydration; the endothelium barrier and pump functions should both be recovered to achieve the recovery of corneal swelling and opacity [ 182 , 183 , 184 , 185 , 186 ]. Noteworthy, BPC 157 therapy commences after cornea perforation.…”

Electrical signaling in control of ocular cell behaviors

“…To remain transparent, corneal water balance/hydration level (deturgesence) must be regulated within a specific physiological range (Donn et al, 1959; Klyce, 1975, 1977; Klyce and Crosson, 1985; Klyce and Wong, 1977; Maurice, 1951, 1967, 1972; Reinach et al, 2008b). Transport of ions coupled with water transport regulate the osmolarity balance between the corneal stroma, the anterior chamber, and the tear fluid, thus regulating deturgesence (Edelhauser, 2006).…”

Ionic Components of Electric Current at Rat Corneal Wounds

“…The corneas of different species have different mechanisms of ion transport. In rabbits, for example, sodium is transported inward, which is surprising since this does not seem to favor water removal from the stroma [53], [54].…”

Stable Gastric Pentadecapeptide BPC 157—Possible Novel Therapy of Glaucoma and Other Ocular Conditions

“…Namely, maintained (recovered) corneal transparency (and thereby maintenance of visual function) implies that the therapy may successfully recover the integrity of all its components (i.e., epithelium, stroma, and endothelium) [ 181 , 182 ]. Moreover, in general terms, the prevented/reversed corneal swelling should include the recovered metabolic and functioning as diffusion barriers to the fluid (tears or aqueous humor) of the epithelium and endothelium, in particular [ 182 , 183 , 184 , 185 , 186 ]. This should be achieved given the major role of maintaining corneal hydration; the endothelium barrier and pump functions should both be recovered to achieve the recovery of corneal swelling and opacity [ 182 , 183 , 184 , 185 , 186 ].…”

“…Moreover, in general terms, the prevented/reversed corneal swelling should include the recovered metabolic and functioning as diffusion barriers to the fluid (tears or aqueous humor) of the epithelium and endothelium, in particular [ 182 , 183 , 184 , 185 , 186 ]. This should be achieved given the major role of maintaining corneal hydration; the endothelium barrier and pump functions should both be recovered to achieve the recovery of corneal swelling and opacity [ 182 , 183 , 184 , 185 , 186 ]. Noteworthy, BPC 157 therapy commences after cornea perforation.…”

Electrical signaling in control of ocular cell behaviors

“…To remain transparent, corneal water balance/hydration level (deturgesence) must be regulated within a specific physiological range (Donn et al, 1959; Klyce, 1975, 1977; Klyce and Crosson, 1985; Klyce and Wong, 1977; Maurice, 1951, 1967, 1972; Reinach et al, 2008b). Transport of ions coupled with water transport regulate the osmolarity balance between the corneal stroma, the anterior chamber, and the tear fluid, thus regulating deturgesence (Edelhauser, 2006).…”