1961
DOI: 10.1530/jrf.0.0020098
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Abstract: Summary. The interactions of oestriol and progesterone were studied in a series of assays for oestrogenic and progestational activities, and the responses were compared with data on progesterone-oestrone combina¬ tions in the same tests. The vaginal effects of these two oestrogens do not seem to differ, whereas the interactions of oestriol and progesterone are quite different from the interactions of oestrone and progesterone when uterine end-points are considered. Since oestriol is the dominant aromatic stero… Show more

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Cited by 17 publications
(12 citation statements)
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References 19 publications
(12 reference statements)
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“…Since it has been claimed that the relationship of the two hormones in this organ might be one of simple molecular competition at a common site of action (Edgren & Calhoun, 1957 a;Edgren, Elton & Calhoun, 1961 ), it should be possible to neutralize the effects of oestro¬ gens on pregnancy with large doses of progesterone.…”
Section: Introductionmentioning
confidence: 99%
“…Since it has been claimed that the relationship of the two hormones in this organ might be one of simple molecular competition at a common site of action (Edgren & Calhoun, 1957 a;Edgren, Elton & Calhoun, 1961 ), it should be possible to neutralize the effects of oestro¬ gens on pregnancy with large doses of progesterone.…”
Section: Introductionmentioning
confidence: 99%
“…In these studies estrone-induced uterine growth was shown to be blocked by TP and progesterone (Edgren and Calhoun, 1957a)and by DCA and aldosterone (Edgren and Calhoun, 1960a). Estriol-stimulated uterine growth was antagonized by TP, whereas DCA (Edgren and Calhoun, 1960b)and progesterone (Edgren et al, 1960)were ineffective.…”
mentioning
confidence: 93%
“…Uterine growth studies in immature, intact mice had suggested that estrone and estriol have separate sites of action in the uterus (Edgren and Calhoun, 1959). In these studies estrone-induced uterine growth was shown to be blocked by TP and progesterone (Edgren and Calhoun, 1957a)and by DCA and aldosterone (Edgren and Calhoun, 1960a).…”
mentioning
confidence: 99%
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