Studies on the embryotoxic effects of ortho-, meta- and para-xylene

Ungváry, G; Tátrai, Erzsébet; Hudák, Aranka; Barcza, G; Lörincz, M.

doi:10.1016/0300-483x(80)90038-4

Cited by 38 publications

(42 citation statements)

References 8 publications

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“…Acute inhalation LC 50 values have been determined in animals for xylene and its isomers (Hine and Zuidema, 1970;Carpenter et al, 1975a;Harper et al, 1975;Bonnet et al, 1979;Ungvary et al, 1980b). The 4-hour LC 50 value for mixed xylene in rats ranged from 6,350ppm (Hine and Zuidema, 1970) to 6,700 ppm (Carpenter et al,1975a).…”

Section: Discussion Of Health Effects By Route Of Exposurementioning

confidence: 99%

ATSDR Evaluation of Health Effects of Chemicals. V. Xylenes: Health Effects, Toxicokinetics, Human Exposure, and Environmental Fate

et al. 1998

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Xylenes, or dimethylbenzenes, are among the highest-volume chemicals in production. Common uses are for gasoline blending, as a solvent or component in a wide variety of products from paints to printing ink, and in the production of phthalates and polyester. They are often encountered as a mixture of the three dimethyl isomers, together with ethylbenzene. As part of its mandate, the Agency for Toxic Substances and Disease Registry (ATSDR) prepares toxicological profiles on hazardous chemicals found at Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) National Priorities List (NPL) sites that are of greatest concern for public health purposes. These profiles comprehensively summarize toxicological and environmental information. This article constitutes the release of the bulk of this profile (ATSDR, 1995) into the mainstream scientific literature. An extensive listing of known human and animal health effects, organized by route, duration, and end point, is presented. Toxicological information on toxicokinetics, biomarkers, interactions, sensitive subpopulations, reducing toxicity after exposure, and relevance to public health is also included. Environmental information encompasses physical properties, production and use, environmental fate, levels seen in the environment, analytical methods, and a listing of regulations. ATSDR, as mandated by CERCLA (or Superfund), prepares these profiles to inform and assist the public.

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Section: Discussion Of Health Effects By Route Of Exposurementioning

confidence: 99%

ATSDR Evaluation of Health Effects of Chemicals. V. Xylenes: Health Effects, Toxicokinetics, Human Exposure, and Environmental Fate

et al. 1998

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show abstract

“…The lowest concentration of the individual xylene isomers reported to induce adverse effects in studies in animal species following inhalation is 150 mg/nf, in which embryoand fetotoxic effects were observed in the absence of maternal toxicity following continuous exposure of pregnant rats to p-xylene on days 7 to 14 of gestation (Ungvary et at., 1980). This is only slightly less than the LOEL used above in the derivation of a TDI for xylenes.…”

Section: At Similar Concentrations (492 Mg/m 3 For 2 Hours) Transienmentioning

confidence: 97%

Xylenes: Evaluation of risks to health from environmental exposure in Canada

Meek

Chan

1994

Journal of Environmental Science and Health, Part C

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“…Untersuchungen an Ratten, Mäusen oder Kaninchen lieferten keine klaren Hinweise auf Beeinträchtigungen der Fortpflanzungsfähig-keit oder spezifische teratogene Wirkungen von Xylolen [84][85][86][87][88]. Auch hinsichtlich entwicklungsneurotoxischer Wirkungen ist die Evidenz schwach [89][90][91][92][93][94].…”

Section: Reproduktionstoxizitätunclassified

Richtwerte für Dimethylbenzole in der Innenraumluft

Umweltbundesamtes¹

2015

Bundesgesundheitsbl.

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Studies on the embryotoxic effects of ortho-, meta- and para-xylene

Cited by 38 publications

References 8 publications

ATSDR Evaluation of Health Effects of Chemicals. V. Xylenes: Health Effects, Toxicokinetics, Human Exposure, and Environmental Fate

ATSDR Evaluation of Health Effects of Chemicals. V. Xylenes: Health Effects, Toxicokinetics, Human Exposure, and Environmental Fate

Xylenes: Evaluation of risks to health from environmental exposure in Canada

Richtwerte für Dimethylbenzole in der Innenraumluft

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