Studies on the effect of social stress on measures of disease resistance in laboratory mice

Psychological Stress and Antibody Response to Immunization: A Critical Review of the Human Literature

“…37). Notable examples include the suppressive effects of social aggression (38), handling (39), and uncontrollable tail shock (40) on primary response to KLH; and rotation stress (41), restraint stress (42), and social aggression (43,44) on antibody response to inoculation with sheep red blood cells. These experimental studies provide a strong impetus to further examine the association between stress and primary response in humans.…”

Psychological Stress and Antibody Response to Immunization: A Critical Review of the Human Literature

“…37). Notable examples include the suppressive effects of social aggression (38), handling (39), and uncontrollable tail shock (40) on primary response to KLH; and rotation stress (41), restraint stress (42), and social aggression (43,44) on antibody response to inoculation with sheep red blood cells. These experimental studies provide a strong impetus to further examine the association between stress and primary response in humans.…”

Fighting experiences and natural killer cell activity in male laboratory mice

“…The influence of social status (dominance-submission) on immune capability has been studied on several occasions. The results suggest a reduced or slower response to antigenic challenge (with sheep red blood cells) in subordinate mice [Beden and Brain, 1982;19851. The present study attempted to examine the effect of dominancesubordination polarity on the cytotoxic activity of NK cells.…”

Physiological and Pathophysiological Implications of Social Stress in Mammals

“…The earliest evidence of immune suppression in subordinate rodents came from reports of an impaired antibody response to a mitogenic challenge in subordinate mice (121). Subsequent studies have shown subordinate mice to have a reduced agglutination response to immunization with sheep red blood cells (9), as well as fewer plaque‐forming cells (27). Similar conclusions have come from studies of rats, in which subordinate individuals show thymic atrophy and decreased responses to both in vitro and in vivo mitogenic challenges (41, 56, 87).…”

Psychological Stress and Antibody Response to Immunization: A Critical Review of the Human Literature

“…37). Notable examples include the suppressive effects of social aggression (38), handling (39), and uncontrollable tail shock (40) on primary response to KLH; and rotation stress (41), restraint stress (42), and social aggression (43,44) on antibody response to inoculation with sheep red blood cells. These experimental studies provide a strong impetus to further examine the association between stress and primary response in humans.…”

Fighting experiences and natural killer cell activity in male laboratory mice

“…The influence of social status (dominance-submission) on immune capability has been studied on several occasions. The results suggest a reduced or slower response to antigenic challenge (with sheep red blood cells) in subordinate mice [Beden and Brain, 1982;19851. The present study attempted to examine the effect of dominancesubordination polarity on the cytotoxic activity of NK cells.…”

Physiological and Pathophysiological Implications of Social Stress in Mammals

“…The earliest evidence of immune suppression in subordinate rodents came from reports of an impaired antibody response to a mitogenic challenge in subordinate mice (121). Subsequent studies have shown subordinate mice to have a reduced agglutination response to immunization with sheep red blood cells (9), as well as fewer plaque‐forming cells (27). Similar conclusions have come from studies of rats, in which subordinate individuals show thymic atrophy and decreased responses to both in vitro and in vivo mitogenic challenges (41, 56, 87).…”

Psychological Stress and Antibody Response to Immunization: A Critical Review of the Human Literature

“…37). Notable examples include the suppressive effects of social aggression (38), handling (39), and uncontrollable tail shock (40) on primary response to KLH; and rotation stress (41), restraint stress (42), and social aggression (43,44) on antibody response to inoculation with sheep red blood cells. These experimental studies provide a strong impetus to further examine the association between stress and primary response in humans.…”

Fighting experiences and natural killer cell activity in male laboratory mice

“…The influence of social status (dominance-submission) on immune capability has been studied on several occasions. The results suggest a reduced or slower response to antigenic challenge (with sheep red blood cells) in subordinate mice [Beden and Brain, 1982;19851. The present study attempted to examine the effect of dominancesubordination polarity on the cytotoxic activity of NK cells.…”

Physiological and Pathophysiological Implications of Social Stress in Mammals

“…The earliest evidence of immune suppression in subordinate rodents came from reports of an impaired antibody response to a mitogenic challenge in subordinate mice (121). Subsequent studies have shown subordinate mice to have a reduced agglutination response to immunization with sheep red blood cells (9), as well as fewer plaque‐forming cells (27). Similar conclusions have come from studies of rats, in which subordinate individuals show thymic atrophy and decreased responses to both in vitro and in vivo mitogenic challenges (41, 56, 87).…”