Studies on the Constituents of Umbelliferae Plants. II. Isolation of the Active Principles of Ligusticum Root

Mitsuhashi, Hiroshi; Nagai, Ukon; Muramatsu, Toshiya; Tashiro, Hatsue

doi:10.1248/cpb.8.243

Cited by 37 publications

(27 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(1), Coniferyl Ferulate (2), and Falcarindiol 3.50 (1H, m)] spectra, which were identical with those of the authentic compound. Compound 1 occurred in the C. officinale rhizome entirely as the free steroid.…”

Section: Pregnenolonementioning

confidence: 57%

See 1 more Smart Citation

Studies on the constituents of umbelliferae plants. XV Constituents of Cnidium officinale : Occurrence of pregnenolone, coniferylferulate and hydroxyphthalides.

Kobayashi

Fujita

Mitsuhashi

1987

CHEMICAL & PHARMACEUTICAL BULLETIN

Self Cite

View full text Add to dashboard Cite

Pregnenolone (1), coniferylferulate (2) and nine mono-and dihydroxyphthalide derivatives (5-13) were isolated from the commercial C. officinale rhizome. Their structures were determined from the spectroscopic data and the dihydroxyphthalides senkyunolide-H (11) and-1 (12) and senkyunolide-J (13) were synthesized from the major components ligustilide (14) and senkyunolide-A (16), respectively. These oxygenated phthalides were absent in the fresh C. officinale rhizome and they were shown to be derived from the major volatile phthalides during storage of the crude drug. Coniferylferulate (2) also decomposes partly during storage, giving ferulic acid.

show abstract

Section: Pregnenolonementioning

confidence: 57%

“…The components eluted were as follows: non-polar alkylphthalides (frs. [2][3][4][5][6][7][8][9][10][11][12][13][14]. 4-7 and 10 (frs.…”

Section: Glycolation Of Ligustilidementioning

confidence: 99%

Studies on the constituents of umbelliferae plants. XV Constituents of Cnidium officinale : Occurrence of pregnenolone, coniferylferulate and hydroxyphthalides.

Kobayashi

Fujita

Mitsuhashi

1987

CHEMICAL & PHARMACEUTICAL BULLETIN

Self Cite

View full text Add to dashboard Cite

show abstract

“…Column chromatography is the benchmark method for the isolation of natural products, with silica gel being the most widely used adsorbent (Mitsuhashi et al 1960). In order to collect the separated materials and components, visualized by TLC, column chromatography is used.…”

Section: Column Chromatographymentioning

confidence: 99%

Characterization of Piriformospora indica Culture Filtrate

et al. 2013

View full text Add to dashboard Cite

“…This plant also affects GABA and 5-HT receptors (Liao et al, 1995), further explaining the ameliorative effect of Yokukansan on BPD symptoms (Miyaoka et al, 2007a). A. acutiloba contains alkylphthalide derivatives and furanocoumarins, both of which have been shown to possess acetylcholinesterase inhibitory activity (Mitsuhashi et al, 1960;Kang et al, 2001). This plant should not be taken with warfarin, heparin, aspirin, nonsteroidal antiinfl ammatory drugs nor other antioxidants as it may affect blood clotting.…”

Section: Plant Components Of Yokukansan and Their Relevant Biologicalmentioning

confidence: 99%

Use of Yokukansan (TJ‐54) in the treatment of neurological disorders: a review

Caires

Steenkamp

2010

Phytotherapy Research

View full text Add to dashboard Cite

Kampo herbal remedies are reported to have a wide range of indications and have attracted attention due to reports suggesting that these remedies are effective when used in disease treatment while maintaining a favourable quality of life. Yokukansan, also known as TJ-54, is composed of seven herbs; Angelica acutiloba, Atractylodes lancea, Bupleurum falcatum, Poria cocos, Glycyrrhiza uralensis, Cnidium officinale, and Uncaria rhynchophylla. Yokukansan is used to treat insomnia and irritability as well as screaming attacks, sleep tremors and hypnic myoclonia, and neurological disorders which include dementia and Alzheimer's disease -the focus of this article.It is concluded that Yokukansan is a versatile herbal remedy with a variety of effects on various neurological states, without reported adverse effects. Traditional herbal medicines consist of a combination of constituents which account for the clinical effect seen. Likewise, the benefits of Yokukansan are probably attributable to the preparation as a whole, rather than to individual compounds.

show abstract

Studies on the Constituents of Umbelliferae Plants. II. Isolation of the Active Principles of Ligusticum Root

Cited by 37 publications

References 0 publications

Studies on the constituents of umbelliferae plants. XV Constituents of Cnidium officinale : Occurrence of pregnenolone, coniferylferulate and hydroxyphthalides.

Studies on the constituents of umbelliferae plants. XV Constituents of Cnidium officinale : Occurrence of pregnenolone, coniferylferulate and hydroxyphthalides.

Characterization of Piriformospora indica Culture Filtrate

Use of Yokukansan (TJ‐54) in the treatment of neurological disorders: a review

Contact Info

Product

Resources

About