Studies on the Complex Nitritoid Crisis After the Intravenous Administration of Arsenicals

Rosen, Isadore

doi:10.1001/archderm.1924.02360270045009

Cited by 10 publications

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“…MISCELLANEOUS Rosen, Müller and Myers 87 have shown that, in all instances, there is a diminution in the number of peripheral leukocytes following the intravenous administration of arsphenamine. Excretion of arsenic is greatly accelerated by thiosulphate.…”

Section: Sodium Thiosulphatementioning

confidence: 94%

Review of the Literature on Syphilis

McBride¹

1926

Arch Pediatr Adolesc Med

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Since the last review of syphilis in this journal, several new antisyphilitic remedies have been brought forward and several that have had some previous use have attained greater prominence. Among the new preparations sulpharsphenamine and flumerin seem of definite merit. Bismuth, which was suggested for use in treatment many years ago, has had its usefulness established during the past few years.Tryparsamide has been extensively employed in cases of neurosyphilis.Perhaps of greater importance than these additions to our means of treatment of syphilis is the fact, only recently generally recognized, that in sodium thiosulphate, a drug relatively harmless, we have an excellent remedy for many of the ill effects which may be produced by the antisyphilitic drugs. SULPHARSPHENAMINE Voegtlin, Johnson and Dyer,45 late in 1922, reported the preparation of a new arsenical, namely, sulpharsphenamine, which has some definite advantages over the older arsphenamines in common use. Sulpharsphenamine is quite stable, requires no elaborate technic for administration and may be administered intramuscularly, with only little disturbance to the patient. Certain other advantages are claimed for it by some authors. This drug has not received universal approval, as certain unpleasant and even serious by-effects, such as arsenic dermatitis, are reputed to be more frequent with sulpharsphenamine than with the other arsphenamines.In white rats the minimum lethal dose of sulpharsphenamine is between 320 and 480 mg. per kilogram. No toxic symptoms are pro¬ duced by two thirds of this dose. The maximum toxic effect was manifest within twenty-four hours of the administration. Standing at room temperature twenty-four hours did not increase the toxicity of a solution of sulpharsphenamine. Thus, sulpharsphenamine is much less toxic and more stable than arsphenamine or neo-arsphenamine.The trypanocidal power, as tested in rats infected with Trypanosoma equiperdum, was equal to that of neo-arsphenamine, though the maxi-(Continued from page 116) 45. Voegtlin, C.; Johnson, J. M., and Dyer, Helen: Sulpharsphenamine: Its

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Section: Sodium Thiosulphatementioning

confidence: 94%