Studies on the antihypertensive, antispasmodic, bronchodilator and hepatoprotective activities of the Carum copticum seed extract

Emodin reverses CCl4induced hepatic cytochrome P450 (CYP) enzymatic and ultrastructural changes: Thein vivoevidence

“…Enhanced leakage of these cytoplasmic enzymes into blood directly reflected alteration in hepatic metabolism and damage after CCl 4 administration. Emodin treatment prevented the leakage of these enzymes in a dose dependent manner probably by reviving the structural integrity of the hepatocellular membrane against CCl 4 challenges 34 . These observations were consistent with the hepatoprotective potential of Ventilago leiocarpa against CCl 4 and D‐galactosamine induced hepatotoxicity 35 .…”

“…Emodin treatment prevented the leakage of these enzymes in a dose dependent manner probably by reviving the structural integrity of the hepatocellular membrane against CCl4 challenges. 34 These observations were consistent with the hepatoprotective potential of Ventilago leiocarpa against CCl4 and D-galactosamine induced hepatotoxicity. 35 Histopathological observations showed severe damage in hepatocytes, which support the alterations observed in biochemical assays.…”

Emodin reverses CCl4induced hepatic cytochrome P450 (CYP) enzymatic and ultrastructural changes: Thein vivoevidence

“…Enhanced leakage of these cytoplasmic enzymes into blood directly reflected alteration in hepatic metabolism and damage after CCl 4 administration. Emodin treatment prevented the leakage of these enzymes in a dose dependent manner probably by reviving the structural integrity of the hepatocellular membrane against CCl 4 challenges 34 . These observations were consistent with the hepatoprotective potential of Ventilago leiocarpa against CCl 4 and D‐galactosamine induced hepatotoxicity 35 .…”

“…Emodin treatment prevented the leakage of these enzymes in a dose dependent manner probably by reviving the structural integrity of the hepatocellular membrane against CCl4 challenges. 34 These observations were consistent with the hepatoprotective potential of Ventilago leiocarpa against CCl4 and D-galactosamine induced hepatotoxicity. 35 Histopathological observations showed severe damage in hepatocytes, which support the alterations observed in biochemical assays.…”

Evaluating the Efficacy of Carum Copticum Seeds on the Treatment of Patients with Nonalcoholic Fatty Liver Disease: A Multi-Center, Randomized, Triple–Blind, Placebo-Controlled Clinical Trial Study

“…The methanolic extract of Ajwain also contains hepatoprotective properties. An in vivo study reported that the methanolic extract of Ajwain could protect the liver by avoiding an increase in the serum levels of liver enzymes of AST, ALT, and ALP followed by a normally-lethal dose of paracetamol and preventing CCl4-induced prolongation of pentobarbital sleeping time in mice (23). In the present study, the serum levels of ALT were significantly dropped in patients treated with Ajwain seed extracts compared to the placebo group.…”

Qualitative Phytochemical Analysis of Ajwain (Trachyspermum Ammi) From North-West Iran

“…The identification of these family of compounds further supports claims of the use of this plants as a traditional medicine as these compounds have valuable amoebicidal, antifugal and anti-inflammatory properties 12,13 . They have stimulating and tnifying effects on the muscles when consumed and this probably accounts for their use in enhancing male potency.…”

Emodin reverses CCl4induced hepatic cytochrome P450 (CYP) enzymatic and ultrastructural changes: Thein vivoevidence

“…Enhanced leakage of these cytoplasmic enzymes into blood directly reflected alteration in hepatic metabolism and damage after CCl 4 administration. Emodin treatment prevented the leakage of these enzymes in a dose dependent manner probably by reviving the structural integrity of the hepatocellular membrane against CCl 4 challenges 34 . These observations were consistent with the hepatoprotective potential of Ventilago leiocarpa against CCl 4 and D‐galactosamine induced hepatotoxicity 35 .…”

“…Emodin treatment prevented the leakage of these enzymes in a dose dependent manner probably by reviving the structural integrity of the hepatocellular membrane against CCl4 challenges. 34 These observations were consistent with the hepatoprotective potential of Ventilago leiocarpa against CCl4 and D-galactosamine induced hepatotoxicity. 35 Histopathological observations showed severe damage in hepatocytes, which support the alterations observed in biochemical assays.…”

Evaluating the Efficacy of Carum Copticum Seeds on the Treatment of Patients with Nonalcoholic Fatty Liver Disease: A Multi-Center, Randomized, Triple–Blind, Placebo-Controlled Clinical Trial Study

“…The methanolic extract of Ajwain also contains hepatoprotective properties. An in vivo study reported that the methanolic extract of Ajwain could protect the liver by avoiding an increase in the serum levels of liver enzymes of AST, ALT, and ALP followed by a normally-lethal dose of paracetamol and preventing CCl4-induced prolongation of pentobarbital sleeping time in mice (23). In the present study, the serum levels of ALT were significantly dropped in patients treated with Ajwain seed extracts compared to the placebo group.…”

Qualitative Phytochemical Analysis of Ajwain (Trachyspermum Ammi) From North-West Iran

“…The identification of these family of compounds further supports claims of the use of this plants as a traditional medicine as these compounds have valuable amoebicidal, antifugal and anti-inflammatory properties 12,13 . They have stimulating and tnifying effects on the muscles when consumed and this probably accounts for their use in enhancing male potency.…”

Emodin reverses CCl4induced hepatic cytochrome P450 (CYP) enzymatic and ultrastructural changes: Thein vivoevidence

“…Enhanced leakage of these cytoplasmic enzymes into blood directly reflected alteration in hepatic metabolism and damage after CCl 4 administration. Emodin treatment prevented the leakage of these enzymes in a dose dependent manner probably by reviving the structural integrity of the hepatocellular membrane against CCl 4 challenges 34 . These observations were consistent with the hepatoprotective potential of Ventilago leiocarpa against CCl 4 and D‐galactosamine induced hepatotoxicity 35 .…”

“…Emodin treatment prevented the leakage of these enzymes in a dose dependent manner probably by reviving the structural integrity of the hepatocellular membrane against CCl4 challenges. 34 These observations were consistent with the hepatoprotective potential of Ventilago leiocarpa against CCl4 and D-galactosamine induced hepatotoxicity. 35 Histopathological observations showed severe damage in hepatocytes, which support the alterations observed in biochemical assays.…”

Evaluating the Efficacy of Carum Copticum Seeds on the Treatment of Patients with Nonalcoholic Fatty Liver Disease: A Multi-Center, Randomized, Triple–Blind, Placebo-Controlled Clinical Trial Study

“…The methanolic extract of Ajwain also contains hepatoprotective properties. An in vivo study reported that the methanolic extract of Ajwain could protect the liver by avoiding an increase in the serum levels of liver enzymes of AST, ALT, and ALP followed by a normally-lethal dose of paracetamol and preventing CCl4-induced prolongation of pentobarbital sleeping time in mice (23). In the present study, the serum levels of ALT were significantly dropped in patients treated with Ajwain seed extracts compared to the placebo group.…”

Qualitative Phytochemical Analysis of Ajwain (Trachyspermum Ammi) From North-West Iran

“…The identification of these family of compounds further supports claims of the use of this plants as a traditional medicine as these compounds have valuable amoebicidal, antifugal and anti-inflammatory properties 12,13 . They have stimulating and tnifying effects on the muscles when consumed and this probably accounts for their use in enhancing male potency.…”