Studies on the analgesic, anti-inflammatory and antipyretic effects of Parquetina nigrescens leaf extract

Analgesic and Toxicity Studies of Aminoacetylenic Isoindoline-1,3-dione Derivatives

“…The first phase (early, acute phase) starts immediately after administration of formalin and diminishes within 10 min whereas the second phase (late, tonic phase) starts at 15 min after formalin administration and lasts for 30 min after pain induction [17–19]. The first and the second phases of formalin test correspond to neurogenic and inflammatory pain, respectively [18, 20].…”

“…Ulcers were scored using arbitrary scale where 0 = no lesion, 0.5 = hyperaemia, 1 = one or two slight lesions, 3 = very severe lesions, and 4 = mucosa full of lesions. Ulcer index (UI) was calculated as mean ulcer scores ± SEM [19]. …”

Analgesic and anti-inflammatory activities of 11-O-galloylbergenin

“…Carrageenan-induced paw edema model is thought to be a biphasic event. In early phase histamine and serotonin are released, then peak at 180 min to release of kininlike substances, while in the late phase prostaglandins, proteases and lysozymes are released (Olajide et al, 1999;Owoyele et al, 2009;Zhang et al, 2009). The results obtained indicated that 11-Ogalloylbergenin has significantly (P < 0.05) inhibited the formation of rat paw edema, both in early and the late phases.…”

Analgesic, anti-inflammatory and anti-diarrheal activities of ethanolic leaf extract of Typhonium trilobatum L. Schott

“…The previous scientific studies have been reported that alkaloids, flavonoids and tannins are known to inhibit prostaglandin synthetase that is responsible for its antinociceptive and anti-inflammatory effects [31][32][33][34][35][36][37][38] . Therefore antinociceptive and anti-inflammatory effect of the extract may be due to the presence of flavonoids, tannins, and alkaloids either singly or in combination.…”