Studies on the alkaloid composition of the Hawaiian Baby Woodrose Argyreia nervosa , a common legal high

Paulke, Alexander; Kremer, Christian; Wunder, Cora; Wurglics, Mario; Schubert‐Zsilavecz, Manfred; Toennes, Stefan W.

doi:10.1016/j.forsciint.2015.02.011

Cited by 16 publications

(9 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Indeed, the divinatory hallucinogenic properties of these three climbing vines are due to psychoactive alkaloids exclusively present in the plants seeds. The principal psychoactive alkaloids identified in the seeds are ergine (lysergamide, lysergic acid amide, LSA) and isoergine, compounds able to induce psychoactive effects like those from lysergic acid diethylammide (LSD), but with fewer intensity [ 27 , 28 ].…”

Section: Resultsmentioning

confidence: 99%

Herbal Highs: Review on Psychoactive Effects and Neuropharmacology

Graziano

Orsolini

Rotolo

et al. 2017

View full text Add to dashboard Cite

Background: A new trend among users of new psychoactive substances’ the consumption of “herbal highs”: plant parts containing psychoactive substances. Most of the substances extracted from herbs, in old centuries were at the centre of religious ceremonies of ancient civilizations. Currently, these herbal products are mainly sold by internet web sites and easily obtained since some of them have no legal restriction.Objective: We reviewed psychoactive effects and neuropharmacology of the most used “herbal highs” with characterized active principles, with studies reporting mechanisms of action, pharmacological and subjective effects, eventual secondary effects including intoxications and/or fatalitiesMethod: The PubMed database was searched using the following key.words: herbal highs, Argyreia nervosa, Ipomoea violacea and Rivea corymbosa; Catha edulis; Datura stramonium; Piper methysticum; Mitragyna speciosa.Results: Psychoactive plants here reviewed have been known and used from ancient times, even if for some of them limited information still exist regarding subjective and neuropharmacological effects and consequent eventual toxicity when plants are used alone or in combination with “classical” drugs of abuse.Conclusion: Some “herbal highs” should be classified as harmful drugs since chronic administration has been linked with addiction and cognitive impairment; for some others taking into consideration only the recent trends of abuse, studies investigating these aspects are lacking.

show abstract

Section: Resultsmentioning

confidence: 99%

Herbal Highs: Review on Psychoactive Effects and Neuropharmacology

Graziano

Orsolini

Rotolo

et al. 2017

View full text Add to dashboard Cite

show abstract

“…The results are shown in Table 1 . Ergine and ergometrine were identified by comparing the retention time (RT) and parent ion m/z , and fragmentation spectra of standards and samples, and for the other compounds, identification was possible by comparing acquired fragmentation spectra to the detailed results already published [ 17 , 18 ]. One should note that in the case of ergine, the first peak originates from ergine and isoergine and it has the same RT as ergine standard used in the experiments.…”

Section: Resultsmentioning

confidence: 99%

“…Methods of determination of ergot alkaloids from other plants infected by Claviceps fungi, such as grass and cereals, require a large amount of sample and a laborious extraction procedure [ 13 – 16 ]. In recent works of Paulke et al with detailed qualitative analysis of ergot alkaloids in Argyreia nervosa seeds, a simple but time-consuming maceration was used [ 17 , 18 ], with no information about efficiency of the process. To the authors’ best knowledge, advanced extraction methods, such as microwave-assisted extraction (MAE) or ultrasound-assisted extraction in ultrasound bath (UAE-B) or with the use of sonotrode (UAE-S) have not yet been used for analytical purposes.…”

Section: Introductionmentioning

confidence: 99%

Identification and determination of ergot alkaloids in Morning Glory cultivars

et al. 2016

View full text Add to dashboard Cite

Seeds of plants from Ipomoea genera contain numerous ergot alkaloids, including psychoactive ergine and ergometrine, and are often abused as so-called “legal highs.” In this work, an analytical method for determination of ergine and ergometrine, and identification of other alkaloids was developed, optimized, and validated. Three extraction techniques, ultrasound-assisted extraction in bath, or with sonotrode, and microwave-assisted extraction were evaluated, and it was concluded that ultrasonic bath is the most suitable technique for extraction of ergot alkaloids. The extraction method was later optimized using a Doehlert experimental design with response surface methodology and used together with the optimized LC-Q-TOF-MS method. The analytical procedure was validated in terms of recovery and matrix effect, repeatability, and intermediate precision. Limits of detection and quantification were 1.0 and 3.0 ng mL–1, respectively, and were sufficient for determination of ergot alkaloids in Ipomoea seeds. The analysis revealed that from five kinds of seeds purchased from different vendors, only three contained ergot alkaloids. Concentration of alkaloids and their relative abundance was similar in samples representative for whole seeds packs; however, when single seeds were analyzed, significant discrepancies in ergine and ergometrine concentrations were detected.Graphical AbstractIdentification of six ergot alkaloids and determination of ergine and ergometrine in Morning glory seeds using the ultrasound-assisted extraction followed the LC-MS analysisElectronic supplementary materialThe online version of this article (doi:10.1007/s00216-016-9322-5) contains supplementary material, which is available to authorized users.

show abstract

“…Rivea corymbose (L)], morning glories (Ipomoea tricolor) [162], and Hawaiian baby woodrose (Argyreia nervosa) (Fig. 17) [163]. The Aztecs called the seeds of Turbina corymbosa Ololiuhqui and of Ipomoea tricolor Tlitliltzin (in Nahuatl).…”

Section: Lysergic Acid Derivatives From Plantsmentioning

confidence: 99%

Migraine drugs

2023

View full text Add to dashboard Cite

According to recent studies, migraine affects more than 1 billion people worldwide, making it one of the world’s most prevalent diseases. Although this highly debilitating illness has been known since ancient times, the first therapeutic drugs to treat migraine, ergotamine (Gynergen) and dihydroergotamine (Dihydergot), did not appear on the market until 1921 and 1946, respectively. Both drugs originated from Sandoz, the world’s leading pharmaceutical company in ergot alkaloid research at the time. Historically, ergot alkaloids had been primarily used in obstetrics, but with methysergide (1-methyl-lysergic acid 1′-hydroxy-butyl-(2S)-amide), it became apparent that they also held some potential in migraine treatment. Methysergide was the first effective prophylactic drug developed specifically to prevent migraine attacks in 1959. On the basis of significantly improved knowledge of migraine pathophysiology and the discovery of serotonin and its receptors, Glaxo was able to launch sumatriptan in 1992. It was the first member from the class of triptans, which are selective 5-HT1B/1D receptor agonists. Recent innovations in acute and preventive migraine therapy include lasmiditan, a selective 5-HT1F receptor agonist from Eli Lilly, the gepants, which are calcitonin gene-related peptide (CGRP) receptor antagonists discovered at Merck & Co and BMS, and anti-CGRP/receptor monoclonal antibodies from Amgen, Pfizer, Eli Lilly, and others. Graphical abstract

show abstract

Studies on the alkaloid composition of the Hawaiian Baby Woodrose Argyreia nervosa , a common legal high

Cited by 16 publications

References 26 publications

Herbal Highs: Review on Psychoactive Effects and Neuropharmacology

Herbal Highs: Review on Psychoactive Effects and Neuropharmacology

Identification and determination of ergot alkaloids in Morning Glory cultivars

Migraine drugs

Contact Info

Product

Resources

About