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Cited by 50 publications
(10 citation statements)
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“…Six subjects received 12 mg and four received 25 mg each. The maximum temperature reached in the group receiving 12 mg was 38.30 C (one subject), and in the group receiving 25 mg, 380 C (one subject (8,9). The activity of lithocholic acid and its conjugates demonstrated in this study makes these monohydroxy compounds of special interest in this regard, although these substances may prove to be only the most potent of a series of pharmacologically active related steroids.…”
Section: Methods and Resultsmentioning
confidence: 68%
“…Six subjects received 12 mg and four received 25 mg each. The maximum temperature reached in the group receiving 12 mg was 38.30 C (one subject), and in the group receiving 25 mg, 380 C (one subject (8,9). The activity of lithocholic acid and its conjugates demonstrated in this study makes these monohydroxy compounds of special interest in this regard, although these substances may prove to be only the most potent of a series of pharmacologically active related steroids.…”
Section: Methods and Resultsmentioning
confidence: 68%
“…The blank value of the method was determined with either water or plasma obtained from pa- 10 We gratefully acknowledge the assistance of Dr. Marvin Zelen, Experimental Statistics Branch, National Cancer Institute. tients who had had ablative endocrine procedures for breast cancer.…”
Section: Comments On Methodsmentioning
confidence: 99%
“…Results from these two types of experiments with mononuclear cells are summarized in the left-hand bar in Fig. 8 (24) have indicated that there is approximately 1 ,ug/100 ml of plasma. When etiocholanolone is injected (25,26), it is rapidly conjugated, cleared from plasma, and excreted in the urine in conjugated form, primarily as the glucosiduronate.…”
Section: Resultsmentioning
confidence: 99%