Studies on paracetamol-induced lipid peroxidation

Short day photoperiod protects against acetaminophen-induced heptotoxicity in rats

“…Increased lipid peroxidation in acetaminophen toxicity is believed to be a consequence of increased interaction between cellular lipids and acetaminophen metabolites (Albano et al, 1983). This observation is consistent with previous studies reporting decreased cellular reduced glutathione activities, increased malondialdehyde production and promotion of lipid productions in both in vitro and in vivo models of acetaminophen-hepatotoxicity (Fairhurst et al, 1982;Albano et al, 1983).…”

Short day photoperiod protects against acetaminophen-induced heptotoxicity in rats

“…Increased lipid peroxidation in acetaminophen toxicity is believed to be a consequence of increased interaction between cellular lipids and acetaminophen metabolites (Albano et al, 1983). This observation is consistent with previous studies reporting decreased cellular reduced glutathione activities, increased malondialdehyde production and promotion of lipid productions in both in vitro and in vivo models of acetaminophen-hepatotoxicity (Fairhurst et al, 1982;Albano et al, 1983).…”

Effect of colchicine on acetaminophen‐induced liver damage

“…On the basis of these considerations, we decided to study the effect of colchicine on APAPinduced liver damage since it appears possible that colchicine might act by preventing, or inhibiting, lipid peroxide formation that can be induced by APAP through a radical mechanism (5,7). Indeed the results reported in the present paper show that colchicine strongly inhibits liver peroxide formation and damage induced by APAP intoxication.…”

“…Since GSH is known to decrease early after APAP intoxication (5), we decided to study it at different times. Fig.…”

Effect of Cistus laurifolius L. leaf extracts and flavonoids on acetaminophen-induced hepatotoxicity in mice

“…Lipid peroxidation probably occurs simultaneously with the proposed covalent binding of the active metabolite of acetaminophen. Since the former process is known to cause severe and extensive membrane damage, it may be a very important factor in acetaminophen-induced liver necrosis (Fairhurst et al, 1982).…”

Short day photoperiod protects against acetaminophen-induced heptotoxicity in rats

“…Increased lipid peroxidation in acetaminophen toxicity is believed to be a consequence of increased interaction between cellular lipids and acetaminophen metabolites (Albano et al, 1983). This observation is consistent with previous studies reporting decreased cellular reduced glutathione activities, increased malondialdehyde production and promotion of lipid productions in both in vitro and in vivo models of acetaminophen-hepatotoxicity (Fairhurst et al, 1982;Albano et al, 1983).…”

Effect of colchicine on acetaminophen‐induced liver damage

“…On the basis of these considerations, we decided to study the effect of colchicine on APAPinduced liver damage since it appears possible that colchicine might act by preventing, or inhibiting, lipid peroxide formation that can be induced by APAP through a radical mechanism (5,7). Indeed the results reported in the present paper show that colchicine strongly inhibits liver peroxide formation and damage induced by APAP intoxication.…”

“…Since GSH is known to decrease early after APAP intoxication (5), we decided to study it at different times. Fig.…”

Effect of Cistus laurifolius L. leaf extracts and flavonoids on acetaminophen-induced hepatotoxicity in mice

“…Lipid peroxidation probably occurs simultaneously with the proposed covalent binding of the active metabolite of acetaminophen. Since the former process is known to cause severe and extensive membrane damage, it may be a very important factor in acetaminophen-induced liver necrosis (Fairhurst et al, 1982).…”

Short day photoperiod protects against acetaminophen-induced heptotoxicity in rats

“…Increased lipid peroxidation in acetaminophen toxicity is believed to be a consequence of increased interaction between cellular lipids and acetaminophen metabolites (Albano et al, 1983). This observation is consistent with previous studies reporting decreased cellular reduced glutathione activities, increased malondialdehyde production and promotion of lipid productions in both in vitro and in vivo models of acetaminophen-hepatotoxicity (Fairhurst et al, 1982;Albano et al, 1983).…”

Effect of colchicine on acetaminophen‐induced liver damage

“…On the basis of these considerations, we decided to study the effect of colchicine on APAPinduced liver damage since it appears possible that colchicine might act by preventing, or inhibiting, lipid peroxide formation that can be induced by APAP through a radical mechanism (5,7). Indeed the results reported in the present paper show that colchicine strongly inhibits liver peroxide formation and damage induced by APAP intoxication.…”

“…Since GSH is known to decrease early after APAP intoxication (5), we decided to study it at different times. Fig.…”

Effect of Cistus laurifolius L. leaf extracts and flavonoids on acetaminophen-induced hepatotoxicity in mice

“…Lipid peroxidation probably occurs simultaneously with the proposed covalent binding of the active metabolite of acetaminophen. Since the former process is known to cause severe and extensive membrane damage, it may be a very important factor in acetaminophen-induced liver necrosis (Fairhurst et al, 1982).…”