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“…7. To the Takebe et al 1971Takebe et al , 1974Sato et al 1975). Russell et al (1969) showed that dexamethasone implanted bilaterally in the anterior pituitary inhibited ACTH release after scald in amounts which were ineffective against scald when given intravenously.…”
Section: Resultsmentioning
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“…7. To the Takebe et al 1971Takebe et al , 1974Sato et al 1975). Russell et al (1969) showed that dexamethasone implanted bilaterally in the anterior pituitary inhibited ACTH release after scald in amounts which were ineffective against scald when given intravenously.…”
Section: Resultsmentioning
“…In rats pretreated with a single injection of dexamethasone (25 pg/200g boby weight) 22 h prior to the experiments, continuous infusion of 318 pgof dexamethasone significantly suppressed the hypothalamic CRF content, whereas infusion of 504 pg of dexameth asone failed to decrease the hypothalamic CRF content in the rats not pretreated with dexamethasone. This finding sug gests that a latent period after the injection of dexamethasone is needed for the appearance of the inhibitory action of syn thetic steriods at the level of hypothalamus.It is well known that treatment with glucocorticoid de creases the hypothalamic CRF content [10,15,17,18]. reported an increase in the hypothalamic CRF activity after stimuli (ether anesthesia) and an inhibi tion of the response to stimuli by corticoid in normal rats.…”
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