Studies on bladder carcinogens in the human environment I. Naphthylamines produced by pyrolysis of amino acids

Masuda, Yoshito; Mori, Kazuko; Kuratsune, Masanori

doi:10.1002/ijc.2910020509

Cited by 17 publications

(7 citation statements)

References 7 publications

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“…2-NA is formed in the pyrolysis of nitrogen-containing organic matter and can occur in nature (60,61). It may occur in the waste streams from plants where it is produced and used; it has been reported to be present in the effluent from certain dyestuff factories in Japan (62).…”

Section: -Naphthylamine (2-na)mentioning

confidence: 99%

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Occurrence uses and carcinogenicity of arylamines

Chung¹

2015

Front Biosci

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Arylamines are chemically synthesized and contained in oxidants, epoxy polymers, explosives, fungicides, pesticides, colorants, polyurethanes, and used in rubber, pharmacology, cosmetics, and other chemical industries. Many arylamines are ubiquitously present in cigarette smoke, cooking fume hoods, foods, automobile exhaust, industrial sites, etc. Some arylamines can be generated through azo reduction by intestinal, skin, and environmental microorganisms from azo dyes that are widely used. Arylamines can also be generated by reduction of the nitro-group containing polyhydrated hydrocarbons including muntions. Some arylamines are released by burning nitrogen containing organic materials at high temperatures. Some medical drugs are also arylamines. Furthermore, many arylamines are essential constituents of normal metabolism or the result of abnormal metabolism or dietary sources. Some arylamines are mutagenic, carcinogenic or the cause of other kinds of maladies. Some arylamine are considered the major etiological agents of bladder tumors in humans and animals but may also induce other types of cancers in various organs. The organ, tissue, and species specificity of the arylamine-inducing carcinogenesis may be determined by their availability, distribution, and the presence of metabolic activation/detoxicification enzymes of each organ or tissue of different species. The ubiquitous arylamines, therefore, pose serious hazards to human health and environment. This article will address the occurrence, uses, carcinogenicity, and other arylamines-induced diseases.

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Section: -Naphthylamine (2-na)mentioning

confidence: 99%

“…o-Toluidine occurs in the constituents of tobacco smoke (54). Eight U.S. commercial cigarette brands have been found to contain 8.6.-144.3.ng of o-toluidine per cigarette (60). In a study from Turkey (59,64), o-toluidine was found in 34 of the 54 hair dyes tested, at quantities up to 1,547 (µg/g).…”

Section: O-toluidinementioning

confidence: 99%

Occurrence uses and carcinogenicity of arylamines

Chung¹

2015

Front Biosci

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“…Cigarette smoke contains naphthalene and ammonia (6,10), and one may regard their thermically activated forms as precursors of naphthylamines in the hot zones of a cigarette. -Aminoacids could also be another type of precursors as was demonstrated by pyrolysis studies (11).…”

Section: Resultsmentioning

confidence: 91%

Determination of 1-naphthylamine and 2-naphthylamine in Cigarette smoke

Masuda¹,

Hoffmann²

1969

Anal. Chem.

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“…2-Naftyloamina powstaje podczas pirolizy związków organicznych zawierających azot [10][11][12]. Już od 1922 r. produkowano ją w celach handlowych, powszechnie wykorzystując przy tym reakcję 2-naftolu z amoniakiem i siarczynem amonu [13].…”

Section: Wstępunclassified

A new method for the determination of naphatylamines in workplace air for occupational exposure assessment

Jeżewska¹,

Kondej²,

Woźnica³

2021

Med Pr

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Wstęp: Naftyloaminy (NA), tzn. 1-naftyloamina (1-NA) oraz 2-naftyloamina (2-NA) i jej sole (chlorowodorek i octan 2-naftyloaminy), to bezbarwne krystaliczne ciała stałe. Znalazły one zastosowanie m.in. w produkcji farb i barwników. W Unii Europejskiej sklasyfikowano 1-NA jako substancję toksyczną, a 2-NA i jej sole jako substancje rakotwórcze kategorii 1A. Celem pracy było opracowanie nowej metody oznaczania NA, która umożliwi ich oznaczanie w środowisku pracy w zakresie stężeń 0,3-6 µg/m 3. Materiał i metody: Metoda polega na zatrzymaniu NA na filtrze zaimpregnowanym kwasem siarkowym(VI). Po rozpuszczeniu w wodzie, zalkalizowaniu roztworem wodorotlenku sodu i ekstrakcji metanolem na kolumienkach Oasis HLB roztwory w metanolu analizowano z zastosowaniem wysokosprawnego chromatografu cieczowego z detektorem fluorescencyjnym. Wyniki: Opracowana metoda umożliwia oznaczanie 1-NA oraz 2-NA i jej soli w zakresie stężeń 0,3-6 µg/m 3. Granica wykrywalności (limit of detection-LOD) wynosi 81 pg/ml dla 1-NA i 80,6 pg/ml dla 2-NA. Wnioski: Metoda charakteryzuje się dobrą precyzją i dokładnością, spełnia wymagania zawarte w normie europejskiej PN-EN 482 i może być wykorzystywana przez laboratoria higieny pracy do wykonywania pomiarów zawartości 1-NA oraz 2-NA i jej soli w powietrzu na stanowiskach pracy w celu oceny narażenia pracowników na te substancje. Med. Pr. 2021;72(2) Słowa kluczowe: metoda analityczna, powietrze na stanowiskach pracy, HPLC, inżynieria środowiska, nauki o zdrowiu, naftyloamina

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Studies on bladder carcinogens in the human environment I. Naphthylamines produced by pyrolysis of amino acids

Cited by 17 publications

References 7 publications

Occurrence uses and carcinogenicity of arylamines

Occurrence uses and carcinogenicity of arylamines

Determination of 1-naphthylamine and 2-naphthylamine in Cigarette smoke

A new method for the determination of naphatylamines in workplace air for occupational exposure assessment

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