Studies of Transplanation Immunity in Hamsters

Billingham, R. E.; Hildemann, W. H.

doi:10.1111/j.1749-6632.1959.tb40844.x

Cited by 19 publications

(4 citation statements)

References 14 publications

(3 reference statements)

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“…The hamster cheek pouch is an ideal site for the implantation of tissues and cells, both from other species and humans (Lutz and Patt, 1952;Handler et al, 1956;Resnick et al, 1960), since it is not an immunologically privileged site and immunosuppressive and immunostimulating agents can modulate the intensity of the local immune response (Shklar et al, 1979). Transplantability of HCPC I cells to randombred hamsters rests on the monomorphic aspect of their major histocompatibility complex (Billingham and Hildemann, 1958;Palm et al, 1967). This peculiarity serves to illustrate the efficacy of DNA vaccination against HER-2 in a genetically heterogeneous (not inbred) population displaying some features similar to those in human.…”

Section: Discussionmentioning

confidence: 99%

Anti-HER-2 DNA vaccine protects Syrian hamsters against squamous cell carcinomas

et al. 2005

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This paper illustrates the efficacy of DNA vaccination through electroporation in the prevention of oral transplantable carcinoma in Syrian hamsters. At 21 and 7 days before tumour challenge, 19 hamsters were vaccinated with plasmids coding for the extracellular and transmembrane domains of rat HER-2 receptor (EC-TM plasmids), whereas 19 control hamsters were injected intramuscularly with the empty plasmid. Immediately following plasmid injection, hamsters of both groups received two square-wave 25 ms, 375 V cm À1 electric pulses via two electrodes placed on the skin of the injection area. At day 0, all hamsters were challenged in the submucosa of the right cheek pouch with HER-2-positive HCPC I cells established in vitro from an 7,12-dimethylbenz[a]anthraceneinduced oral carcinoma. This challenge gave rise to HER-2-positive buccal neoplastic lesions in 14 controls (73.37%), compared with only seven (36.8%, Po0.0027) vaccinated hamsters. In addition, the vaccinated hamsters displayed both a stronger proliferative and cytotoxic response than the controls and a significant anti-HER-2 antibody response. Most of the hamsters that rejected the challenge displayed the highest antibody titres. These findings suggest that DNA vaccination may have a future in the prevention of HER-2-positive human oral cancer.

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Section: Discussionmentioning

confidence: 99%

Anti-HER-2 DNA vaccine protects Syrian hamsters against squamous cell carcinomas

et al. 2005

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“…These findings indicate, therefore, as Billingham and Hildeman have recently reemphasized (30), that when the genetic difference between donor and recipient is small the survival of skin grafts is correspondingly increased, the longer survival times probably occurring when more closely related animals are selected from a partially inbred, and therefore still heterogeneous, population. These experiments show that reaction to parathyroid grafts can be so debilitated as to allow their functional survival in the presence of the state of heightened reactivity entailed in a second set response to skin from the same donor.…”

Section: Da Y9mentioning

confidence: 76%

Parathyroid Transplants in Rats

Russell

Gittes

1959

The Journal of Experimental Medicine

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1. A reliable method of parathyroid grafting in rats, and of assessing the functional state of such grafts in terms of blood calcium has been devised. 2. Parathyroid homografts between rats of proven genetic diversity may be rejected as promptly as skin; but the majority survive for an indefinite period, there being no intermediate class. 3. Surviving parathyroid grafts in this genetically diverse combination invariably succumb in the presence of the immunity induced by a later skin graft from the same donor. 4. Parathyroid grafts between rats of less genetic diversity have usually responded to skin graft-induced immunity in the same manner as those between more dissimilar rats. The less divergent group, however, revealed an occasional persistent functioning of parathyroid grafts even in the face of the sensitivity incidental to an accelerated reaction to skin. 5. The hypothesis is presented that the parathyroid tissue of the rats studied was deficient in effective transplantation antigens as compared with those of their skin. This weakness in apparent antigenicity may be a reflection of a deficiency in production, availability, or content of antigens in the tissue transferred.

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“…Billingham & Hildemann [1958] carried out experiments with skin homografts on four different colonies of golden hamsters in this country, and found that the fate of skin homografts of hamsters from different colonies varied consider¬ ably. With certain combinations, the animals rejected the grafts vigorously, whereas with other colony combinations the grafts survived as well as intra-colony grafts.…”

Section: Pregnancy and Lactationmentioning

confidence: 99%

“…On the other hand, Adams [1958] reported that skin homografts had been made successfully between golden and albino hamsters from four different sources in the United States. Billingham & Hildemann [1958] have discussed possible reasons for the feeble nature of the homograft reaction in hamsters. Adams et al [1956] had postulated that the hamsters' ability to respond to tissue homografts might be defective.…”

Section: Pregnancy and Lactationmentioning

confidence: 99%

Orthotopic Ovarian Grafts in the Golden Hamster

Parrott¹

1959

Journal of Endocrinology

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1. Interstrain orthotopic ovarian homografts have been made between hamsters of two strains, golden and dark-eared albino, maintained at the National Institute for MedicalResearch.2. The golden hamster recipients were sterilized with irradiation directed to the ovaries whilst the rest of the body was shielded with lead.3. Ovaries from albino donors were grafted orthotopically into irradiated golden hamsters which were then paired with albino males. The genetic identification of young from the graft was possible; hybrid offspring between golden and albino hamsters are golden in colour so that any albino offspring must have been derived from the graft.4. The homograft reaction between golden and albino hamsters was negligible; out of fifty grafted golden hamsters forty-five had established grafts and twenty-seven of them were fertile. Altogether forty litters, containing at least one offspring derived from a graft, were obtained. 5. The comparative importance of immunological and endocrine factors in the establishment of ovarian grafts and factors influencing the fertility of orthotopic ovarian grafts are discussed.

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Studies of Transplanation Immunity in Hamsters

Cited by 19 publications

References 14 publications

Anti-HER-2 DNA vaccine protects Syrian hamsters against squamous cell carcinomas

Anti-HER-2 DNA vaccine protects Syrian hamsters against squamous cell carcinomas

Parathyroid Transplants in Rats

Orthotopic Ovarian Grafts in the Golden Hamster

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