1926
DOI: 10.1021/ja01419a026
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Abstract: The reaction between acetamide and alkyl bromides, showing its general applicability to the synthesis of substituted acetamides and the corresponding amines, has been investigated.A possible mechanism for the reaction, accounting for the production of ammonium bromide, has been suggested.1. 2.During a study of the pharmacological properties of some iso-urea derivatives, it was found by one of us1 that carbethoxy-ethyl-isourea had well-marked physiological action, the chief effects being a mild central depressi… Show more

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Cited by 4 publications
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“…1/[σ 2 (Fo 2 ) + (aP) 2 + bP] where P = (Fo 2 + 2Fc 2 )/3 was introduced. Towards the end of the refinement, it was determined that the Cl2 atom was disordered.…”
Section: X-ray Crystallographymentioning
confidence: 99%
See 1 more Smart Citation
“…1/[σ 2 (Fo 2 ) + (aP) 2 + bP] where P = (Fo 2 + 2Fc 2 )/3 was introduced. Towards the end of the refinement, it was determined that the Cl2 atom was disordered.…”
Section: X-ray Crystallographymentioning
confidence: 99%
“…[EtOC(=O)N(H)C(=N + H2)NH2]Cl.½H2O (1), is described. While the precursor compound, EtOC(=O)N(H)C(=NH)NH2, was first prepared about 150 years ago [1,2], a search of the literature revealed no definitive evidence for 1 although hydrochloride salts have been alluded…”
Section: Introductionmentioning
confidence: 99%