1995
DOI: 10.1001/archderm.131.1.31
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Studies in patients with corticosteroid contact allergy. Understanding cross-reactivity among different steroids

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Cited by 72 publications
(70 citation statements)
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“…While the ®xation mechanism of the corticosteroid molecules to the skin proteins in contact allergy reactions has yet to be completely elucidated, it seems that the reaction site involved in the formation of the antigenic complex is not the a,b-unsaturated ketone (a``classic'' reactive site) at position C 3 ±C 4 of the steroid moiety, which is much too``congested'', but the a-ketoaldehyde formed after oxidation of the alcohol function at C 21 . The presence of the reactive binding site on the lateral chain of corticosteroids is in good agreement with cross-reaction patterns, a major in¯uence being modi®cations on cycle D (43).…”
Section: Corticosteroid Haptenssupporting
confidence: 70%
See 1 more Smart Citation
“…While the ®xation mechanism of the corticosteroid molecules to the skin proteins in contact allergy reactions has yet to be completely elucidated, it seems that the reaction site involved in the formation of the antigenic complex is not the a,b-unsaturated ketone (a``classic'' reactive site) at position C 3 ±C 4 of the steroid moiety, which is much too``congested'', but the a-ketoaldehyde formed after oxidation of the alcohol function at C 21 . The presence of the reactive binding site on the lateral chain of corticosteroids is in good agreement with cross-reaction patterns, a major in¯uence being modi®cations on cycle D (43).…”
Section: Corticosteroid Haptenssupporting
confidence: 70%
“…Budesonide was found to be a marker for different groups of corticosteroids: not only for other acetonides (group B, to which it theoretically belongs) but also for certain esters (group D), such as hydrocortisone-17-butyrate and prednicarbate. These clinical observations were fully supported by conformational analysis of the electronic shape of the corticosteroids involved (43). Groups A, B, and D were found to be highly homogeneous within each group in terms of molecular structures, and signi®cant differences were observed between the groups.…”
Section: Cross-reactivity Patternsmentioning
confidence: 58%
“…In 1989, based on structural and clinical characteristics, Coopman et al (111) classified CSs into four reactivity groups, namely Groups A, B, C and D, the volume occupied by substituents on the D ring of the CS molecule being a critical element of CS binding to skin proteins. In 1995, Lepoittevin et al (112) carried out conformational analysis of the observed cross-reactivities between CSs, which supported this classification. Groups A, B and D are indeed very homogenous in terms of molecular structure and significant differences are only evident between CSs of different groups.…”
Section: Cross Vs Concomitant Reactionsmentioning
confidence: 86%
“…Thus, while the agent applied Budesonide and Group D2. Budesonide can be considered as a unique case in the following sense: its acetal function is actually an equal mixture of the R and S diastereoisomers (112). Both R and S diastereoisomers can develop cross-reactions with Group B CSs, but only the S diastereoisomer can cross-react with Group D2 CSs (115).…”
Section: Cross Vs Concomitant Reactionsmentioning
confidence: 99%
“…In fact, as it has already been demonstrated for allergy to β-lactams [14], the molecular model is very useful to explain the cross-reactivity among the various molecules [15]. …”
Section: Discussionmentioning
confidence: 99%