Natalia V. Varlakhanova, Frances J.D. Alvarez, Tyler M. Brady, Bryan A. Tornabene, Christopher J. Hosford, Joshua S. Chappie, Peijun Zhang, Marijn G.J. Ford
Abstract:Dynamin-related proteins (DRPs) are large multidomain GTPases required for diverse membrane-remodeling events. DRPs self-assemble into helical structures, but how these structures are tailored to their cellular targets remains unclear. We demonstrate that the fungal DRP Vps1 primarily localizes to and functions at the endosomal compartment. We present crystal structures of a Vps1 GTPase-bundle signaling element (BSE) fusion in different nucleotide states to capture GTP hydrolysis intermediates and concomitant …
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