volume 85, issue 1, P3-9 2016
DOI: 10.1002/prot.25179
View full text
|
|
Share

Abstract: Toll-like receptors (TLRs) recognize common structural patterns in diverse microbial molecules and play central roles in the innate immune response. The structures of extracellular domains and their ligand complexes of several TLRs have been determined by X-ray crystallography. Here, we discuss recent advances on structures and activation mechanisms of TLRs. Despite the differences in interaction areas of ligand with TLRs, the extracellular domains of TLRs all adopt horseshoe-shaped structures and the overall …

Expand abstract

Search citation statements

Order By: Relevance

Citation Types

0
50
0

Paper Sections

0
0
0
0
0

Publication Types

0
0
0
0

Relationship

0
0

Authors

Journals