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Cited by 81 publications
(39 citation statements)
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“…Another group possibly involved in the interaction of aspartame with the sweetness receptor is the methyl carboxylate group (COOCH 3 ) denoted as an E] binding site following the terminology proposed by Tinti and Nofre (1991) for the binding sites of sweeteners. In fact, the interaction of this group is not essential to the sweetness of this dipeptide since the replacement of the COOCH3 group of aspartame (Figure 4a) by a CH 3 group leads to a compound (Figure 4b) which is still about 50 times sweeter than sucrose in man (Mazur et al, 1970(Mazur et al, , 1973. Consequently, in aspartame, the COOCH 3 group must be considered as only a sweetness amplifying group, increasing the sweetness potency by a factor of about 3.5 in comparison with a CH 3 group.…”
Section: Discussionmentioning
confidence: 99%
“…Another group possibly involved in the interaction of aspartame with the sweetness receptor is the methyl carboxylate group (COOCH 3 ) denoted as an E] binding site following the terminology proposed by Tinti and Nofre (1991) for the binding sites of sweeteners. In fact, the interaction of this group is not essential to the sweetness of this dipeptide since the replacement of the COOCH3 group of aspartame (Figure 4a) by a CH 3 group leads to a compound (Figure 4b) which is still about 50 times sweeter than sucrose in man (Mazur et al, 1970(Mazur et al, , 1973. Consequently, in aspartame, the COOCH 3 group must be considered as only a sweetness amplifying group, increasing the sweetness potency by a factor of about 3.5 in comparison with a CH 3 group.…”
Section: Discussionmentioning
confidence: 99%
“…Identification of the parabolic descriptors PRECLAV calculates for the sweetness power SP multilinear equations of type (1). Although it is difficult to believe that the sweetness power dependency on various molecular features (descriptors) is linear, these equations have a reasonable predictive value.…”
Section: Obtaining the Homogenized Calibration Setmentioning
confidence: 99%
“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] These researches focus on QSAR (Quantitative Structure Activity Relationship) studies, molecular modeling and conformational analysis and aim to establish the structural features of aspartyl-dipeptide derivatives that favour the activation of sweet taste receptors and to predict the sweetness potency of such molecules. Recent studies on molecular bases of sweet taste in the family of sweet taste dipeptide ligands revealed the fact that some Narylalkyl and other substituted aspartyl dipeptide derivatives have a sweetness potency of 3 -CH(OH)-CH 2 -biciclo-2Me-6,6'diMe-…”
Section: Introductionmentioning
confidence: 99%
“…3, Table 3) Dependent property: Log(RS), values taken from literature [18][19][20][21][22][23][24][25][26][27][28][29][30][31] Training set: 33 molecule (Table 3, The prediction for the training set molecules is very good (F and K CV have high values). The prediction for the testing set molecules is poorer (K = 0.5714).…”
Section: Qsar Study #3mentioning
confidence: 99%