“…When employing contrast agents for MRI, contrast agent shall possess the following distinct features for better imaging (Zhou et al, 2019): (a) Nano-size, achieve the maximum recognition; (b) diagnosis with high accuracy; (c) Compatibility, non-cytotoxic and biocompatible; (d) Stability, both chemical and photochemical stable; (e) Metabolism; renal excretion from body (Qin et al, 2007;Huang et al, 2010;Botar et al, 2020).…”