ABSTRACTSimple models are presented that describe the rules for almost all the packing that occurs between and among a-helices and pleated sheets. These packing rules, together with the primary and secondary structures, are the major determinants of the three-dimensional structure of proteins. Twenty-six years ago, Pauling and his colleagues (1, 2) presented the a-helix and the parallel and antiparallel pleated sheets as models for the local folding (secondary structure) of the polypeptide chain in proteins. …
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