Structure elucidation of a human melanocortin-4 receptor specific orthosteric nanobody agonist
Christel Menet,
Toon Laeremans,
Thomas Fontaine
et al.
Abstract:The melanocortin receptor 4 (MC4R) belongs to the melanocortin receptor family of G-protein coupled receptors and is a key switch in the leptin-melanocortin molecular axis that controls hunger and satiety. Brain-produced hormones such as α-melanocyte-stimulating hormone (agonist) and agouti-related peptide (inverse agonist) regulate the molecular communication of the MC4R axis but are promiscuous for melanocortin receptor subtypes and induce a wide array of biological effects. Using a conformation-selective Co… Show more
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