Structure-biocompatibility relationship of dendritic polyglycerol derivatives

Khandare, Jayant; Mohr, Andreas; Calderón, Marcelo; Welker, Pia; Licha, Kai; Haag, Rainer

doi:10.1016/j.biomaterials.2010.02.001

Cited by 118 publications

(110 citation statements)

References 38 publications

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“…18) in an attempt to explore the effects of post-modification of hyperbranched polyglycerol with primary amines in the favorable 1,2-orientation [144]. In a previous study, the polyglycerolamine architecture, which consists of primary amine groups spread all around the polyglycerol structure, has showed promising properties as a prospective system for gene delivery, namely high charge with a relative low cytotoxicity, and an optimal charge/pH behavior so far as the buffering capacity is concerned [139]. Of all the polyglycerol systems analyzed for gene transfection, the hyperbranched polyglycerolamine showed the highest affinity towards DNA fragments, according to the ethidium bromide displacement assay.…”

Section: Hyperbranched Polyglycerolmentioning

confidence: 98%

“…This could substantially increase the internalization of active components, specifically into targeted cells, enhancing the therapeutic benefits and decreasing the adverse side effects [136][137][138]. Recently we demonstrated that post-modified hyperbranched polyglycerol presents sufficiently low zeta potentials, lower interactions with serum albumin, enhanced cellular uptake, and higher cellular viability on human hematopoietic cell line U-937, to be considered a promising candidate for a systematic delivery of therapeutic agents [139].…”

Section: Hyperbranched Polyglycerolmentioning

confidence: 98%

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Hyperbranched Polyamines for Transfection

Fischer

Calderón

Haag

2010

Topics in Current Chemistry

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The successful application of gene therapy through DNA transfection into the cell is still a great challenge in ongoing research. Hyperbranched polyamines are highly branched macromolecules, and have gained significant attention in the last two decades, due to their relative ease of preparation, their shape, and their multi-functionality.This review deals with the syntheses of various hyperbranched polyamines that are prepared through a one-step polymerization process. Furthermore, we present the current status of polyamines as gene carriers and describe their versatility, and their properties such as structure-property dependency, gene transfection efficiency, and cytotoxicity profiles of hyperbranched polyamines.

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Section: Hyperbranched Polyglycerolmentioning

confidence: 98%

Section: Hyperbranched Polyglycerolmentioning

confidence: 98%

Hyperbranched Polyamines for Transfection

Fischer

Calderón

Haag

2010

Topics in Current Chemistry

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“…The cell compatibility results show that the hbPGs are as safe as linear PEG polymers or dextran, which indicates the suitability of hbPG derivatives in delivering therapeutic agents systemically. 122 In an interesting work, Haag and coworkers have recently observed a molecular mass and size-dependent cellular uptake of hbPG, indicating a molecular weight/size optimum around 200 kDa/12 nm. 123 Their data suggest that the HIGHLIGHT higher molecular weight hbPGs (40-870 kDa) predominantly accumulate in the cytoplasm and that endocytotic uptake can be suppressed for lower molecular weights (2-20 kDa).…”

Section: Biocompatibilitymentioning

confidence: 99%

Hyperbranched aliphatic polyether polyols

Schömer

Schüll

Frey

2012

J. Polym. Sci. A Polym. Chem.

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Hyperbranched polymers, dendritic macromolecules with branch-on-branch structures, have become an important polymer class since the early 1990s. They combine several advantages of the perfectly branched dendrimers with easy accessibility, typically in a one-step synthesis. Hyperbranched polyethers are a particularly interesting class of chemically stable and often biocompatible materials. Multifunctional hyperbranched polyethers with controllable molar mass and comparably low polydispersities can been prepared using hydroxyl-functional epoxides or oxetanes for polymerization via anionic and cationic polymerization mechanisms. Here, we review the progress in the preparation, characterization, and application of these uniquely versatile aliphatic polyether polyols. Their unusual mechanical, thermal, and solution properties render them useful for a variety of applications, for example, as building blocks for various complex macromolecular architectures or in biomedical applications.

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“…Type and proportion of surface functional groups have a profound impact on the surface charge of the polymers. [25] In the repeating unit of PSA, the number of primary, secondary, tertiary amino groups and sulfone groups is 0.12, 0.65, 2.25 and 1.05, Scheme 1. Synthesis route of PSA.…”

Section: Zeta-potential Measurementsmentioning

confidence: 99%

Highly Efficient Intracellular Drug Delivery with a Negatively Charged Hyperbranched Polysulfonamine

Chen

Tan

et al. 2011

Macromolecular Bioscience

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Efficient intracellular translocation is achieved using an easily prepared hyperbranched polysulfonamine that remains negatively charged at physiological pH. Investigations on the cellular uptake mechanism and the subcellular distribution of PSA are reported. The in vitro cytotoxicity of PSA is found to be low. Using doxorubicin as a model drug, a PSA/drug complex is prepared by electrostatic interaction with a high drug payload that exhibits a controlled release in response to pH. Efficient intracellular drug delivery, strong growth inhibition of tumor cells, and low cytotoxicity to normal cells are observed. The results suggest a possible way to utilize anionic polymers for intracellular delivery of therapeutic moieties or drugs. magnified image

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Structure-biocompatibility relationship of dendritic polyglycerol derivatives

Cited by 118 publications

References 38 publications

Hyperbranched Polyamines for Transfection

Hyperbranched Polyamines for Transfection

Hyperbranched aliphatic polyether polyols

Highly Efficient Intracellular Drug Delivery with a Negatively Charged Hyperbranched Polysulfonamine

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