Structure and variation of the influenza C glycoprotein

Pfeifer, J.B.; Compans, Richard W.

doi:10.1016/0264-410x(85)90101-x

Cited by 2 publications

(2 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Based on published data on residues that could be critical in HEF processing or function (14,44,45,50), we chose to focus on positions 284 and 465 of the HEF protein (amino acid numbering). Indeed, it has been suggested that position 284 of HEF could be involved in receptor binding activity (50), whereas position 465 is located in the peptide fusion domain of HEF (12).…”

mentioning

confidence: 99%

Rescue of Influenza C Virus from Recombinant DNA

Crescenzo-Chaigne

Werf

2007

J Virol

View full text Add to dashboard Cite

The rescue of influenza viruses by reverse genetics has been described only for the influenza A and B viruses. Based on a similar approach, we developed a reverse-genetics system that allows the production of influenza C viruses entirely from cloned cDNA. The complete sequences of the 3 and 5 noncoding regions of type C influenza virus C/Johannesburg/1/66 necessary for the cloning of the cDNA were determined for the seven genomic segments. Human embryonic kidney cells (293T) were transfected simultaneously with seven plasmids that direct the synthesis of each of the seven viral RNA segments of the C/JHB/1/66 virus under the control of the human RNA polymerase I promoter and with four plasmids encoding the viral nucleoprotein and the PB2, PB1, and P3 proteins of the viral polymerase complex. This strategy yielded between 10 3 and 10 4 PFU of virus per ml of supernatant at 8 to 10 days posttransfection. Additional viruses with substitutions introduced in the hemagglutinin-esterase-fusion protein were successfully produced by this method, and their growth phenotype was evaluated. This efficient system, which does not require helper virus infection, should be useful in viral mutagenesis studies and for generation of expression vectors from type C influenza virus.

show abstract

mentioning

confidence: 99%

Rescue of Influenza C Virus from Recombinant DNA

Crescenzo-Chaigne

Werf

2007

J Virol

View full text Add to dashboard Cite

show abstract

“…A clinical study of a small outbreak of ICV during November-December 1978, among employees, demonstrated that ICV illness involved muscle aches, fever, headaches which is clinically indistinguishable from IAV, and ICV patients took longer to recover compared with employees with IAV infections [105]. However, clinical manifestations of ICV in children are reported to have more variable outcomes from upper and lower respiratory infections (cough, rhinitis, wheeziness without temperature, respiratory distress) to encephalopathy [56,118]. A follow-up study of ICV in children in March 1981, showed that four secondary and two tertiary infections had occurred in two years of survey time.…”

Section: Clinical Manifestations/pathobiology Of Icv and Idv In Princ...mentioning

confidence: 99%

Host Range, Biology, and Species Specificity of Seven-Segmented Influenza Viruses—A Comparative Review on Influenza C and D

et al. 2021

View full text Add to dashboard Cite

Other than genome structure, influenza C (ICV), and D (IDV) viruses with seven-segmented genomes are biologically different from the eight-segmented influenza A (IAV), and B (IBV) viruses concerning the presence of hemagglutinin–esterase fusion protein, which combines the function of hemagglutinin and neuraminidase responsible for receptor-binding, fusion, and receptor-destroying enzymatic activities, respectively. Whereas ICV with humans as primary hosts emerged nearly 74 years ago, IDV, a distant relative of ICV, was isolated in 2011, with bovines as the primary host. Despite its initial emergence in swine, IDV has turned out to be a transboundary bovine pathogen and a broader host range, similar to influenza A viruses (IAV). The receptor specificities of ICV and IDV determine the host range and the species specificity. The recent findings of the presence of the IDV genome in the human respiratory sample, and high traffic human environments indicate its public health significance. Conversely, the presence of ICV in pigs and cattle also raises the possibility of gene segment interactions/virus reassortment between ICV and IDV where these viruses co-exist. This review is a holistic approach to discuss the ecology of seven-segmented influenza viruses by focusing on what is known so far on the host range, seroepidemiology, biology, receptor, phylodynamics, species specificity, and cross-species transmission of the ICV and IDV.

show abstract

Structure and variation of the influenza C glycoprotein

Cited by 2 publications

References 25 publications

Rescue of Influenza C Virus from Recombinant DNA

Rescue of Influenza C Virus from Recombinant DNA

Host Range, Biology, and Species Specificity of Seven-Segmented Influenza Viruses—A Comparative Review on Influenza C and D

Contact Info

Product

Resources

About