Structure and function of the rabbit's supraspinatus muscle after resection of its tendon

Björkenheim, Jan-Magnus

doi:10.3109/17453678909149320

Cited by 84 publications

(70 citation statements)

References 3 publications

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“…Several studies have associated these changes with poor clinical outcome [2-4, 7, 8, 10-12, 15, 16, 19, 20, 23]. The natural history of fatty infiltration is described as irreversible and, usually, progressive [3,8,10,14,20]. Indeed, fatty infiltration graded as Stage 2 or higher is associated with a definitive loss of muscular function and, as a result, increases the rate of repair failure and limits the achievable outcome during the postoperative period [18,22].…”

Section: Discussionmentioning

confidence: 99%

Natural History of Fatty Infiltration and Atrophy of the Supraspinatus Muscle in Rotator Cuff Tears

Mélis

DeFranco

Chuinard

et al. 2010

Clinical Orthopaedics &Amp; Related Research

211

153

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Background In some patients nonoperative treatment of a rotator cuff tear is sufficient, while in others it is only the first stage of treatment prior to surgery. Fatty infiltration progresses throughout the nonoperative treatment although it is not known at what point fatty infiltration contributes to poor functional outcomes, absence of healing, or increased rerupture rates. Questions/purposes We therefore identified factors related to the appearance of supraspinatus muscle fatty infiltration, determined the speed of appearance and progression of this phenomenon, and correlated fatty infiltration with muscular atrophy. Methods We retrospectively reviewed 1688 patients with rotator cuff tears and recorded the following: number of tendons torn, etiology of the tear, time between onset of shoulder symptoms and diagnosis of rotator cuff tear. Fatty infiltration of the supraspinatus was graded using either CT or MRI classification. Muscular atrophy was measured indirectly using the tangent sign. Results Moderate supraspinatus fatty infiltration appeared an average of 3 years after onset of symptoms and severe fatty infiltration at an average of 5 years after the onset of symptoms. A positive tangent sign appeared at an average of 4.5 years after the onset of symptoms. Conclusions Our results suggest that rotator cuff repair should be performed before the appearance of fatty infiltration (Stage 2) and atrophy (positive tangent sign)-especially when the tear involves multiple tendons.

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Section: Discussionmentioning

confidence: 99%

Natural History of Fatty Infiltration and Atrophy of the Supraspinatus Muscle in Rotator Cuff Tears

Mélis

DeFranco

Chuinard

et al. 2010

Clinical Orthopaedics &Amp; Related Research

211

153

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“…First, this is an animal study and translation of these findings to the human should be made with caution. The rabbit rotator cuff model is well accepted for investigation of pathologic conditions of muscle because it reproduces the key structural findings for muscle deterioration seen in humans and sheep after detachment of its tendon [29][30][31][32] . This study focused exclusively on the muscle tissue and did not investigate the tendon, primarily because …”

Section: Discussionmentioning

confidence: 99%

Anabolic Steroids Reduce Muscle Damage Caused by Rotator Cuff Tendon Release in an Experimental Study in Rabbits

Gerber

Meyer

Nuss

et al. 2011

Journal of Bone and Joint Surgery

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To our knowledge, this is the first documentation of partial prevention of important muscle alterations after retraction of the supraspinatus musculotendinous unit caused by tendon disruption. Nandrolone decanoate administration in the phase after tendon release prevented fatty infiltration of the supraspinatus muscle and reduced functional muscle impairment caused by myotendinous retraction in this rabbit rotator cuff model, but two of seven rabbits that received the drug developed infections. Background: Muscles of the rotator cuff undergo retraction, atrophy, and fatty infiltration after a chronic tear, and a rabbit

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“…In a rabbit model, sectioning of the supraspinatus tendon resulted in increased adipose tissue in the muscle belly on histologic examination after 4 weeks [2]. The following year, Goutallier et al [12] reported results of CT scans of the shoulder in patients undergoing repair of the rotator cuff.…”

Section: Historymentioning

confidence: 99%

Classifications in Brief: Goutallier Classification of Fatty Infiltration of the Rotator Cuff Musculature

Somerson

Hsu

Gorbaty

et al. 2016

Clinical Orthopaedics &Amp; Related Research

100

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Structure and function of the rabbit's supraspinatus muscle after resection of its tendon

Cited by 84 publications

References 3 publications

Natural History of Fatty Infiltration and Atrophy of the Supraspinatus Muscle in Rotator Cuff Tears

Natural History of Fatty Infiltration and Atrophy of the Supraspinatus Muscle in Rotator Cuff Tears

Anabolic Steroids Reduce Muscle Damage Caused by Rotator Cuff Tendon Release in an Experimental Study in Rabbits

Classifications in Brief: Goutallier Classification of Fatty Infiltration of the Rotator Cuff Musculature

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