Structure and Concentration Capacity of the Kidneys in Brattleboro Rats under Conditions of Long-Term Vasopressin Treatment

Abstract

The function and histochemistry of the kidney were studied in homozygous Brattleboro rats after 28-day treatment with exogenous arginine-vasopressin. The long-lasting effect of the hormone includes normalization of osmotic concentration, decrease in the number of b-glucuronidase granules in the medulla, and increasing content of hyaluronan in the interstitium. These changes promote physiological optimization of the antidiuretic reaction to vasopressin.

Morphological Characteristics of the Inner Medullary Zone in the Kidneys of Brattleboro and Wistar Rats during Blockade of Prostaglandin Synthesis

“…1, c). These data are consistent with the results of previous experiments [1,9]. During blockade of PG synthesis, hyaluronan was identifi ed in the glycocalyx and cytoplasm of interstitial cells (granules of the Hale-positive material; Fig.…”

“…Wistar rats contain a lower number of β-glucuronidase granules than those in control Brattleboro rats (F (1,1799) (epitheliocytes)=1375.13, p<0.001; F (1,405) (interstitial cells)=240.91, p<0.001; Fig. 2, a; Table 1).…”

“…Comparison of β-glucuronidase distribution showed that this enzyme is accumulated in epitheliocytes of the collecting ducts in all experimental animals. The degree of these changes depended on neurohypophyseal function of animals (F (1,1799) =69.31, p<0.001). Published data show that variations in the size of granules illustrate differences in the location of β-glucuronidase [2].…”