Search citation statements

Order By: Relevance
Select...
2
1
1
1
9
0

Year Published

2006
2006
2011
2011

Publication Types

Select...
4

Relationship

3
1

Authors

Journals

1
9
0
Order By: Relevance
“…Binding affinities for the dopamine, serotonin and norepinephrine transporters were determined by the ability of the drug to displace the radiolabeled ligands [ 3 H]WIN 35,428, [ 3 H]citalopram, and [ 3 H]nisoxetine, respectively, from the monoamine transporters obtained from rat brain tissue using previously reported assays. 40, 43,44 The binding affinities of all compounds listed in Table 1 were initially determined for the DAT. The compounds that exhibited DAT binding affinities with K i values < 100 nM were evaluated at the serotonin and norepinephrine transporters to determine transporter selectivity.…”
Section: Resultsmentioning
See 1 more Smart Citation
Create an account to read the remaining citation statements from this report. You will also get access to:
  • Search over 1b+ citation statments to see what is being said about any topic in the research literature
  • Advanced Search to find publications that support or contrast your research
  • Citation reports and visualizations to easily see what publications are saying about each other
  • Browser extension to see Smart Citations wherever you read research
  • Dashboards to evaluate and keep track of groups of publications
  • Alerts to stay on top of citations as they happen
  • Automated reference checks to make sure you are citing reliable research in your manuscripts
  • 14 day free preview of our premium features.

Trusted by researchers and organizations around the world

Over 100,000 students researchers, and industry experts at use scite

See what students are saying

rupbmjkragerfmgwileyiopcupepmcmbcthiemesagefrontiersapsiucrarxivemeralduhksmucshluniversity-of-gavle
“…Binding affinities for the dopamine, serotonin and norepinephrine transporters were determined by the ability of the drug to displace the radiolabeled ligands [ 3 H]WIN 35,428, [ 3 H]citalopram, and [ 3 H]nisoxetine, respectively, from the monoamine transporters obtained from rat brain tissue using previously reported assays. 40, 43,44 The binding affinities of all compounds listed in Table 1 were initially determined for the DAT. The compounds that exhibited DAT binding affinities with K i values < 100 nM were evaluated at the serotonin and norepinephrine transporters to determine transporter selectivity.…”
Section: Resultsmentioning
“…In fact the greater than 1000-fold SERT/DAT selectivity observed for 22e is among the highest reported for any DAT ligand. 2830, 44 In addition, 22e was also selective for DAT over NET (NET/DAT: 625) albeit less than the SERT.…”
Section: Resultsmentioning
“…In this review we have highlighted the most potent and selective molecules from each structural class; however, several other unique structures have been identified that possess either moderate affinity and or moderate selectivity for the DAT. Rhoden and colleagues prepared meperidine derivatives (E19) having altered N-and ester substituents [94]. Krunic and co-workers studied a series of 3-aryl substituted trop-2-enes (E20) [95].…”
Section: D29mentioning
“…20-23 Previously, we have reported on a series of derivatives of meperidine ( 1 ) that exhibited modest potency and selectivity for the SERT (Figure 2). 21,22 However, unlike the prototypical SSRIs fluoxetine and paroxetine, the meperidine analogues 2 lack a secondary amine and two aromatic moieties common to the SERT pharmacophore. 24,25 In light of these deficiencies it was of interest to examine this class of meperidine-based SERT ligands to determine if SERT potency could be improved and the monoamine transporter selectivity influenced by the addition of a second strategically placed aryl ring system.…”
Section: Introductionmentioning