volume 271, issue 1-2, P21-30 2004
DOI: 10.1016/j.ijpharm.2003.10.018
View full text
|
|
Share

Abstract: The redox chemistry and pharmacological studies of the novel blue ruthenium(III)-catecholamine complexes were investigated in aqueous medium and compared to the free catecholamines. The [Ru(III)(NH3)4(catecholamine)]+ can be oxidized or reduced reversibly in one electron redox couples in aqueous solution. This is in contrast to the free catecholamines, which has a complicated electrochemical behavior due to coupled protonation process. The introduction of the ruthenium group reduces the intrinsic efficacy of t…

expand abstract