Structural variation of solid core and thickness of porous shell of 1.7μm core–shell silica particles on chromatographic performance: Narrow bore columns

One‐Pot Synthesis of Spheres‐on‐Sphere Silica Particles from a Single Precursor for Fast HPLC with Low Back Pressure

“…[ 28 ] So far, these core-shell silica particles have been prepared via the use of preformed nonporous silica particles followed by synthesizing a porous coating, [ 11 ] attaching smaller particles, [ 16 , 29 ] or the multiple step LbL technique. [27][28][29] A one-pot synthesis of core-shell particles would be highly advantageous, offering potential benefi ts on reaction time, easier quality control, materials costs, and process simplicity for facile scale-up.…”

Theoretical investigation of diffusion along columns packed with fully and superficially porous particles

“…(17), the Landauer diffusion model in Eqs. (21) and (22) or the Torquato's model Eqs. (48) and (49).…”

“…No fewer than three manufacturers are now competing to provide such packing materials including Halo (Advanced Material Technologies, Wilmington, DE, USA), Kinetex (Phenomenex, Torrance, CA, USA), and Poroshell120 (Agilent Technologies, Little Falls, DE, USA). At least two academic groups are developing similar materials [21,22]. The performance of these columns is now equivalent to that of columns packed with sub-2 m particles over which they have the important advantages of requiring markedly lower operating pressures and exhibiting lesser efficiency loss due to thermal effects at high flow rates [10,12,13].…”

Measurement and Modeling of Extra-Column Effects Due to Injection and Connections in Capillary Liquid Chromatography

“…Consequently, extracolumn effects attributed to instrumentation that reduce the measured separation efficiency are more prominent than with standard HPLC columns [1][2][3][4][5][6][7][8][9][10][11]. Similar to previous eras when column technology began to exceed the limitations of commercial equipment [12,13], extra-column band broadening (ECBB) is now seeing increasing attention as an important factor that needs to be accounted for and reduced as much as possible [14][15][16][17][18].…”