Structural properties of the human corpus callosum: Multimodal assessment and sex differences

Age, sex, and puberty related development of the corpus callosum: a multi-technique diffusion MRI study

“…The profiles across the corpus callosum for FA and MD are consistent with previous reports in adults (Caminiti et al 2013;Bjornholm et al 2017). The profile of vic followed a very similar pattern to FA, although vic did not…”

“…This similarity might be explained by regional differences in membrane permeability, whereby larger axon diameters can lead to alterations in the radial DWI signal with subsequent regional differences in AFD (Raffelt et al 2012). Myelin water fraction is highest in the body of the corpus callosum, likely due to the larger fibre diameters seen in this region (Liu et al 2010;Bjornholm et al 2017). Therefore the bigger, more myelinated axons in the body may influence the AFD measurement in this region.…”

Effects of nerve bundle geometry on neurotrauma evaluation

“…As mentioned in section 2, this study is carried out assuming an idealized geometry of a nerve bundle to limit the complexity and computational cost arising from the use of 3D morphological images of neuronal structure . Then, although the axon caliber has been shown to vary in animals , and in humans, here, we have assumed fibers with diameters of about 1 to 2 μm only, as examples of human nerve fibers. However, the human brain is made of fibers with a wider range of diameters .…”

“…Then, although the axon caliber has been shown to vary in animals , and in humans, here, we have assumed fibers with diameters of about 1 to 2 μm only, as examples of human nerve fibers. However, the human brain is made of fibers with a wider range of diameters . So, the caliber of fibers considered in this paper is representative of small fibers ( d < 0.4 μm) only found in the human corpus callosum, but not large fibers ( d > 5 μm). Thus, future works may consider testing this modeling approach for a wider range of axon caliber to understand the distribution of functional and mechanical failure within the human brain under mechanical loading .…”

“…The bundle model is a section of an idealized geometry of a nerve bundle consisting of 4 identical parallel cylindrical unmyelinated or myelinated fibers (see Figure ). The diameters of these fibers are within the range of small fibers of the human corpus callosum . We consider the case of 2 scaled nerve bundle models with a ratio of 2:1, where the nerve fibers inside follow the same ratio, keeping the same thickness for the nerve membrane .…”