2008
DOI: 10.1016/j.jbiomech.2008.08.013
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Structural properties of fourth-generation composite femurs and tibias

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Cited by 276 publications
(207 citation statements)
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“…Second, we chose to use a synthetic tissue surrogate. Although cadaveric tissue testing may be considered the gold standard in producing results with the highest level of clinical translation and acceptance, prior studies have validated the surrogates against human tissue from a mechanical perspective [3,4,6,7,16,17]. The use of synthetic specimens also eliminates bone quality and heterogeneous geometry as confounding factors, which we considered to be an important a priori consideration to adequately interrogate biomechanical differences between the methods of fixation.…”
Section: Discussionmentioning
confidence: 99%
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“…Second, we chose to use a synthetic tissue surrogate. Although cadaveric tissue testing may be considered the gold standard in producing results with the highest level of clinical translation and acceptance, prior studies have validated the surrogates against human tissue from a mechanical perspective [3,4,6,7,16,17]. The use of synthetic specimens also eliminates bone quality and heterogeneous geometry as confounding factors, which we considered to be an important a priori consideration to adequately interrogate biomechanical differences between the methods of fixation.…”
Section: Discussionmentioning
confidence: 99%
“…A synthetic tissue surrogate was chosen because of standardized geometry, homogeneous material properties, and prior laboratory work that has validated the surrogates against cadaveric human bone with comparative results for axial, torsional, and four-point bending stiffness as well as failure mechanism and failure load under different loading conditions [3,4,6,7,16,17]. Additionally, the use of a tissue surrogate eliminates potentially confounding variables associated with fresh-frozen cadaveric tissue, including bone quality and anatomic heterogeneity, which may affect biomechanical results and their interpretation.…”
Section: Specimensmentioning
confidence: 99%
“…The synthetic scapulae we used provided a more homogenous test bed than cadaveric specimens, and they are more anatomically relevant than foam blocks as used in previous studies [8,23,33]. Although fatigue testing is not defined for this model, this substrate (fourthgeneration composite bones) has been shown to have similar biomechanical properties to human bone [20,41,42] and has been used by others for glenoid prosthesis testing [34]. Despite their homogeneity, the methods used to manufacture the synthetic scapulae result in circularshaped weak zones in the cortical shell.…”
Section: Discussionmentioning
confidence: 99%
“…The bone geometry is based on a 183-cm, 90-kg male and the mechanical properties simulate those of healthy adult bones of less than 80 years of age [24]. However, it has been proven that the failure modes and typical fracture patterns are close to the ones published for human bones [24,25]. Fixation in osteoporotic patients will most likely fail at lower values.…”
Section: Discussionmentioning
confidence: 99%