Abstract:In Escherichia coli, FtsLB plays a central role in the initiation of cell division, possibly transducing a signal that will eventually lead to the activation of peptidoglycan remodeling at the forming septum. The molecular mechanisms by which FtsLB operates in the divisome, however, are not understood. We present a structural analysis of the FtsLB complex – performed with biophysical, computational and in vivo methods – that establishes the organization of the transmembrane region and proximal coiled coil of t… Show more
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