Structural Modification Influences the Characteristics of Langmuir Monolayers from Aromatic Carboxylic Acids

Dynarowicz-Łątka, Patrycja; Kita, Katarzyna; Milart, Piotr; Dhanabalan, A.; Cavalli, Ailton; Filho, Demétrio A. da Silva; Oliveira, O.N.

doi:10.1006/jcis.2001.7541

Cited by 4 publications

(1 citation statement)

References 21 publications

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“…The potential applications of Langmuir monolayers and Langmuir−Blodgett films (LB) in various physical, chemical and biological fields − have promoted studies on a wide variety of monolayer-forming materials. In contrast with the well-known behavior of traditional amphiphiles used to form monolayers at the air−water interface, very little research on aromatic analogues of aliphatic compounds has so far been conducted. − Some such materials possess interesting optical properties that allow their use in biosensor technology and in nonlinear optical devices 3,4 and allow one to study various biological environments. − For instance, many membrane fluorescent probes are sensitive to bilayer polarity and can be used as fluorescent probes when they are inserted in a film. Then, these molecules can be useful tools to obtain information about different properties of membranes such as the phase state, fluidity, polarity, and microviscosity.…”

Section: Introductionmentioning

confidence: 99%

Surface Pressure−Area Isotherms and Fluorescent Behavior of a ω-6-(N-Methyl-N-alkylamine) Naphthoylalkanoic Acid (MANA)

et al. 2002

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This paper reports the surface pressure−area isotherms for the new fluorescent probe ω-[6-(N-methyl-N-ethylamino)naphthoyl]undecanoic acid (MANA10-2) obtained by changing experimental variables such as the subphase conditions, pH, temperature, and the compression rate. The surface monolayer technique was used in combination with surface fluorescence measurements. Changes in pH and temperature of the aqueous subphase were found to significantly influence isotherm shape. The fluorescent properties of the molecule were studied both in the monolayer and in the subphase. This allowed us to determine the orientation of MANA10-2 on the surface and revealed that the monolayer is dissolved at both low and high pH values and high temperatures. Monolayers were also examined by Brewster angle microscopy. The morphology and size of the domains formed are clearly governed by temperature and the pH of the aqueous subphases. Only with monolayers spread on pure water at 20 °C was the transition from the liquid phase to the condensed phase observed. This was also the only occasion when the monolayers exhibited high macroscopic uniformity. A large number of small bright nuclei (typical of a densely packed two-dimensional phase or a three-dimensional phase) are formed at low surface pressure in the presence of HCl and NaOH subphases (pH 1 and 9, respectively).

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Section: Introductionmentioning

confidence: 99%

Surface Pressure−Area Isotherms and Fluorescent Behavior of a ω-6-(N-Methyl-N-alkylamine) Naphthoylalkanoic Acid (MANA)

et al. 2002

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Influence of apolar group structure on the properties of Langmuir monolayers of polyphenyl carboxylic acids

Dynarowicz-Łątka

Kita

Milart

et al. 2002

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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Edelfosine in Membrane Environment - the Langmuir Monolayer Studies

Dynarowicz-Łątka

Hąc-Wydro

2014

ACAMC

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The Langmuir monolayer technique is one of the methods used to build models of cellular membranes and enables to investigate the interactions of membrane components with other biomolecules. This method has been applied to study the effect of edelfosine - a synthetic alkyl-lysophospholipid analog - on model lipid membranes in order to get insight into its mode of action and selectivity. Edelfosine is mainly known for its anticancer properties, although it is also applied in the treatment of other diseases, like autoimmune, anti-HIV and antiparasitic. In this review we focus on its antitumor activity (although some other aspects of its therapeutic effects are also indicated) and summarize the results obtained so far with use of the monolayer technique. The application of this method evidenced for a key role of cholesterol and membrane rafts in the mechanism of anticancer activity of edelfosine. As regards the selectivity of this drug, the obtained results proved that the difference in fluidity of tumor versus normal cell membrane is important but probably not the only factor determining an easier incorporation of edelfosine into cancer cells. Further studies show that edelfosine is of strong affinity to gangliosides, which may be considered as molecules targeting edelfosine into cancer cell membrane.

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Structural Modification Influences the Characteristics of Langmuir Monolayers from Aromatic Carboxylic Acids

Cited by 4 publications

References 21 publications

Surface Pressure−Area Isotherms and Fluorescent Behavior of a ω-6-(N-Methyl-N-alkylamine) Naphthoylalkanoic Acid (MANA)

Surface Pressure−Area Isotherms and Fluorescent Behavior of a ω-6-(N-Methyl-N-alkylamine) Naphthoylalkanoic Acid (MANA)

Influence of apolar group structure on the properties of Langmuir monolayers of polyphenyl carboxylic acids

Edelfosine in Membrane Environment - the Langmuir Monolayer Studies

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