Structural implications of polyphenolic antioxidants

Halake, Kantappa; Birajdar, Mallinath S.; Lee, Jonghwi

doi:10.1016/j.jiec.2016.01.003

Cited by 69 publications

(37 citation statements)

References 149 publications

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“…Indeed, these compounds have been reported to possess abroad spectrum of biological activities such as anti-inflammatory, anti-invasive, antitumor and antibacterial properties [3][4][5][6]. They are also considered as potentially important synthetic intermediates for the preparation of flavonoids and isoflavonoids, which are widely, present in inedible plants [7][8][9]. Moreover, they have recently been used as simple building blocks for the synthesis of dihydropyridones [10].…”

Section: Introductionmentioning

confidence: 99%

Modified fluorapatite as highly efficient catalyst for the synthesis of chalcones via Claisen–Schmidt condensation reaction

Jioui

Dânoun

Solhy

et al. 2016

Journal of Industrial and Engineering Chemistry

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Section: Introductionmentioning

confidence: 99%

Modified fluorapatite as highly efficient catalyst for the synthesis of chalcones via Claisen–Schmidt condensation reaction

Jioui

Dânoun

Solhy

et al. 2016

Journal of Industrial and Engineering Chemistry

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“…The "phenolic compounds" expression embraces a considerable range of substances that possess an aromatic ring bearing one or more hydroxyl substituents. The structure of natural polyphenols varies from simple molecules, such as phenolic acids, to highly polymerized compounds, such as condensed tannins [1][2][3][4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

“…With regard to the HAT process, a double bond in a substituent favors it, while the -COOH group shows a contrary [8][9][10][11]. In particular, the catechol moiety (1,2-dihydroxybenzene) is considered as an important component of natural antioxidants and for that reason, this is present in many studies [1,12,13]. Contrary to this observation, the resorcinol moiety (1,3-dihydroxybenzene) has received less attention, even though it is also present within the structure of many compounds with high antioxidant capacity, especially resorcinols substituted with alkyl groups that present different chain length and several grades of saturation [14,15].…”

Section: Introductionmentioning

confidence: 99%

The substituent effect on the antioxidant capacity of catechols and resorcinols

2016

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effect. The combination of a double bond with a -COOH group, in the substituent, increases the BDE and reduces the electron donor capacity, and this result suggests that this combination induces a reduction in the antioxidant capacity in one polyphenol compound. In several reports, an intramolecular hydrogen bond has been proposed within to the most stable structure of catechol. However, by using arguments from the atoms in molecules approach and the electron localization function, we show that such an interaction is not relevant to stabilize this conformation and consequently and this is the reason that explains the unimportance of this interaction in the properties studied here and in previous studies.

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“…There are several mechanisms of antioxidants in the literature, concerning polyphenolic compounds (Halake et al, 2016). The initial one, polyphenolic compounds, which was bonded with the iron to manufacture catalytic activity center.…”

Section: Enzymatic Antioxidant Status Mda and Gsh Level In Liver Andmentioning

confidence: 99%

Effects of Salvia Miltiorrhiza extract on the regulation of antioxidant enzyme activities in liver and kidney of rats exposed to TCA

Alnahdi

Ramadan

Farid

et al. 2018

IJAR

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The present study aimed to investigate the protective role of Salvia Miltiorrhiza against Trichloroacetic acid (TCA) induced liver and kidney toxicity in rats. Twenty eight adults Wister albino male rats were divided into 4 equal groups. Group 1 served as control, while group 2 received SM extracts at 200 mg/kg body weight; group 3 was treated with 50 mg/kg/day TCA by gavage daily. Group 4 received the extract at 200 mg/kg body weight and 50 mg/kg/day TCA for two months. A significant increase was observed in liver function, kidney function and MDA (malondialdehyde) levels among the TCA administered animals compared to normal control. Daily oral administration of SM normalized most biochemical changes observed among the TCA treated animals. Histopathologically, higher amount of mononuclear cells infiltration, necrotic cells and few fibroblasts were observed in liver and kidney of TCA treated group. The administration of Salvia Miltiorrhiza extract regulates and decreases liver and kidney damage.

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Structural implications of polyphenolic antioxidants

Cited by 69 publications

References 149 publications

Modified fluorapatite as highly efficient catalyst for the synthesis of chalcones via Claisen–Schmidt condensation reaction

Modified fluorapatite as highly efficient catalyst for the synthesis of chalcones via Claisen–Schmidt condensation reaction

The substituent effect on the antioxidant capacity of catechols and resorcinols

Effects of Salvia Miltiorrhiza extract on the regulation of antioxidant enzyme activities in liver and kidney of rats exposed to TCA

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