Structural differences in hippocampal subfields among schizophrenia patients, major depressive disorder patients, and healthy subjects

Ota, Miho; Sato, Noriko; Hidese, Shinsuke; Teraishi, Toshiya; Maikusa, Norihide; Matsuda, Hiroshi; Hattori, Kotaro; Kunugi, Hiroshi

doi:10.1016/j.pscychresns.2016.11.002

Cited by 51 publications

(66 citation statements)

References 43 publications

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“…Several studies have shown significant correlations between CA1 and CA2/3 volumes and one study between presubiculum and subiculum volumes and positive symptom severity . Additionally, three studies found a relationship between hippocampal subregion volumes and negative symptoms but each with a different region, namely subiculum, CA2/3 and CA4/DG, or CA2 . Finally, CA1 CBV has been found to be associated with overall, positive, and negative symptom severity though these findings were not replicated in a more recent report …”

Section: Discussionmentioning

confidence: 90%

“…The later study found that presubiculum and subiculum volumes were more affected in schizophrenia . Another study found lower CA1 volumes in schizophrenia compared to controls subjects, and lower DG volumes in schizophrenia compared to control and unmedicated subjects with major depressive disorder . Clearly, these findings warrant replication.…”

Section: Discussionmentioning

confidence: 91%

“…Most schizophrenia imaging studies using FreeSurfer to estimate hippocampal subregion volumes published to date have employed the first method and atlas . Three FreeSurfer studies have used the second method with the updated hippocampal subregion segmentation atlas run on top of the FreeSurfer 5.3 whole hippocampal segmentation …”

Section: Resultsmentioning

confidence: 99%

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Hippocampal subregion abnormalities in schizophrenia: A systematic review of structural and physiological imaging studies

Nakahara

Matsumoto

Erp

2018

Neuropsychopharm Rep

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Aim The hippocampus is considered a key region in schizophrenia pathophysiology, but the nature of hippocampal subregion abnormalities and how they contribute to disease expression remain to be fully determined. This study reviews findings from schizophrenia hippocampal subregion volumetric and physiological imaging studies published within the last decade. Methods The PubMed database was searched for publications on hippocampal subregion volume and physiology abnormalities in schizophrenia and their findings were reviewed. Results The main replicated findings include smaller CA1 volumes and CA1 hyperactivation in schizophrenia, which may be predictive of conversion in individuals at clinical high risk of psychosis, smaller CA1 and CA4/DG volumes in first‐episode schizophrenia, and more widespread smaller hippocampal subregion volumes with longer duration of illness. Several studies have reported relationships between hippocampal subregion volumes and declarative memory or symptom severity. Conclusions Together these studies provide support for hippocampal formation circuitry models of schizophrenia. These initial findings must be taken with caution as the scientific community is actively working on hippocampal subregion method improvement and validation. Further improvements in our understanding of the nature of hippocampal formation subregion involvement in schizophrenia will require the collection of structural and physiological imaging data at submillimeter voxel resolution, standardization and agreement of atlases, adequate control for possible confounding factors, and multi‐method validation of findings. Despite the need for cautionary interpretation of the initial findings, we believe that improved localization of hippocampal subregion abnormalities in schizophrenia holds promise for the identification of disease contributing mechanisms.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 91%

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Hippocampal subregion abnormalities in schizophrenia: A systematic review of structural and physiological imaging studies

Nakahara

Matsumoto

Erp

2018

Neuropsychopharm Rep

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“…Individuals with schizophrenia are of particular interest to the hippocampal research community due to the memory impairments characteristic of this disorder. Previous neuroimaging research has furthermore uncovered structural and functional differences (Fornara, Papagno, & Berlingeri, ; Ota et al, ; Pirnia et al, ; Ragland et al, ; Seidman et al, ) linked to hippocampus in schizophrenia. Here, MEG can be used to determine what temporal differences in neural processing might exist for those with this psychiatric condition.…”

Section: Resultsmentioning

confidence: 99%

Characterizing hippocampal dynamics with MEG: A systematic review and evidence‐based guidelines

Ruzich

Crespo-García

Dalal

et al. 2018

Human Brain Mapping

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The hippocampus, a hub of activity for a variety of important cognitive processes, is a target of increasing interest for researchers and clinicians. Magnetoencephalography (MEG) is an attractive technique for imaging spectro‐temporal aspects of function, for example, neural oscillations and network timing, especially in shallow cortical structures. However, the decrease in MEG signal‐to‐noise ratio as a function of source depth implies that the utility of MEG for investigations of deeper brain structures, including the hippocampus, is less clear. To determine whether MEG can be used to detect and localize activity from the hippocampus, we executed a systematic review of the existing literature and found successful detection of oscillatory neural activity originating in the hippocampus with MEG. Prerequisites are the use of established experimental paradigms, adequate coregistration, forward modeling, analysis methods, optimization of signal‐to‐noise ratios, and protocol trial designs that maximize contrast for hippocampal activity while minimizing those from other brain regions. While localizing activity to specific sub‐structures within the hippocampus has not been achieved, we provide recommendations for improving the reliability of such endeavors.

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“…This integral role in memory function indicates that memory impairment results from hippocampal volume loss. Importantly, a reduction of hippocampal subfield volume has been shown in the same brain diseases in which vitamin D deficiency is implicated, including major depressive disorder (Han, Won, Sim, & Tae, 2016;Ota et al, 2017;Samuels, Leonardo, & Hen, 2015), schizophrenia (Ota et al, 2017), Alzheimer's disease (de Flores, La Joie, & Chetelat, 2015;La Joie et al, 2013), and dementia (La Joie et al, 2013). Emerging evidence from several lines of inquiry suggest that vitamin D may contribute to hippocampal volume loss.…”

mentioning

confidence: 99%

Vitamin D deficiency is associated with reduced hippocampal volume and disrupted structural connectivity in patients with mild cognitive impairment

Al-Amin

Bradford

Sullivan

et al. 2018

Human Brain Mapping

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Vitamin D deficiency may exacerbate adverse neurocognitive outcomes in the progression of diseases such as Parkinson's, Alzheimer's, and other dementias. Mild cognitive impairment (MCI) is prodromal for these neurocognitive disorders and neuroimaging studies suggest that, in the elderly, this cognitive impairment is associated with a reduction in hippocampal volume and white matter structural integrity. To test whether vitamin D is associated with neuroanatomical correlates of MCI, we analyzed an existing structural and diffusion MRI dataset of elderly patients with MCI. Based on serum 25‐OHD levels, patients were categorized into serum 25‐OHD deficient (<12 ng/mL, n = 27) or not‐deficient (>12 ng/mL, n = 29). Freesurfer 6.0 was used to parcellate the whole brain into 164 structures and segment the hippocampal subfields. Whole‐brain structural connectomes were generated using probabilistic tractography with MRtrix. The network‐based statistic (NBS) was used to identify subnetworks of connections that significantly differed between the groups. We found a significant reduction in total hippocampal volume in the serum 25‐OHD deficient group especially in the CA1, molecular layer, dentate gyrus, and fimbria. We observed a connection deficit in 13 regions with the right hippocampus at the center of the disrupted network. Our results demonstrate that low vitamin D is associated with reduced volumes of hippocampal subfields and connection deficits in elderly people with MCI, which may exacerbate neurocognitive outcomes. Longitudinal studies are now required to determine if vitamin D can serve as a biomarker for Alzheimer's disease and if intervention can prevent the progression from MCI to major cognitive disorders.

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Structural differences in hippocampal subfields among schizophrenia patients, major depressive disorder patients, and healthy subjects

Cited by 51 publications

References 43 publications

Hippocampal subregion abnormalities in schizophrenia: A systematic review of structural and physiological imaging studies

Hippocampal subregion abnormalities in schizophrenia: A systematic review of structural and physiological imaging studies

Characterizing hippocampal dynamics with MEG: A systematic review and evidence‐based guidelines

Vitamin D deficiency is associated with reduced hippocampal volume and disrupted structural connectivity in patients with mild cognitive impairment

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