Biochemical Pharmacology volume 79, issue 3, P444-454 2010 DOI: 10.1016/j.bcp.2009.08.026 View full text
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Hoda M. Eid, Diane Vallerand, Asim Muhammad, Tony Durst, Pierre S. Haddad, Louis C. Martineau

Abstract: Caffeic acid phenethyl ester (CAPE) has recently been shown to potently stimulate glucose uptake in cultured skeletal muscle cells through the AMPK pathway and therefore to have anti-diabetic potential. We report here that CAPE increases glucose uptake in C2C12 muscle cells by 225+/-21% at 50 microM, and that activation of AMPK is a consequence of the metabolic stress resulting from an uncoupling-type disruption of mitochondrial function (complete uncoupling at 50 microM). We also observe that the therapeutic …

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