2002
DOI: 10.1021/jf011264n
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Abstract: Hydroxytyrosol is quantitatively and qualitatively the principal phenolic antioxidant in olive oil. Recently it was shown that hydroxytyrosol and five metabolites were excreted in urine when hydroxytyrosol was dosed intravenously or orally in an olive oil solution to rats. The conclusive identification of three metabolites of hydroxytyrosol by MS/MS as a monosulfate conjugate, a 3-O-glucuronide conjugate, and 4-hydroxy-3-methoxyphenylacetic acid (homovanillic acid) has been established in this investigation. T… Show more

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Cited by 114 publications
(79 citation statements)
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References 17 publications
(33 reference statements)
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“…The radical scavenging potency of O-methylated hydroxytyrosol was similar and that of the 3-O-glucuronide conjugate was more potent than hydroxytyrosol in vitro, whereas the monosulphate conjugate of hydroxytyrosol was almost devoid of its radical scavenging activity (Tuck et al, 2002). In vivo, however, conjugates might also have less antioxidant activity than the ingested compounds, as was shown for quercetine-glucuronide compared to quercetin (Manach et al, 1998;Day et al, 2000), and O-methylated quercetin also showed less antioxidant activity as compared to quercetin (Manach et al, 1998;Yamamoto et al, 1999).…”
Section: Are Phenols Antioxidants In Vivo?mentioning
confidence: 70%
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“…The radical scavenging potency of O-methylated hydroxytyrosol was similar and that of the 3-O-glucuronide conjugate was more potent than hydroxytyrosol in vitro, whereas the monosulphate conjugate of hydroxytyrosol was almost devoid of its radical scavenging activity (Tuck et al, 2002). In vivo, however, conjugates might also have less antioxidant activity than the ingested compounds, as was shown for quercetine-glucuronide compared to quercetin (Manach et al, 1998;Day et al, 2000), and O-methylated quercetin also showed less antioxidant activity as compared to quercetin (Manach et al, 1998;Yamamoto et al, 1999).…”
Section: Are Phenols Antioxidants In Vivo?mentioning
confidence: 70%
“…We found a recovery of 5-16 mol% of total ingested phenols , which is lower than that reported by others. However, our finding is probably an underestimate because we did not measure metabolites of olive oil phenols, such as O-methylated hydroxytyrosol (3-hydroxy-4-methoxyphenylethanol) in urine (Manna et al, 2000;Visioli et al, 2000a;Caruso et al, 2001;D'Angelo et al, 2001;Tuck et al, 2002). Taken together, data on urinary excretion indicate that at the very least 5% of ingested olive oil phenols is recovered in urine as (glucuronidated) tyrosol and hydroxytyrosol.…”
Section: Bioavailabilitymentioning
confidence: 74%
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