Structural changes in pancreatic acinar cells and β-cells of rat fed with genetically modified corn

Karawya, Fardous S.; Metwally, El Sayed Aly Mohamed

doi:10.4103/1596-2393.200918

Cited by 1 publication

(1 citation statement)

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“…In fact, NO impacts mitochondrial oxidative phosphorylation, which, in turn, inhibits insulin secretion [21]. Mild edema was also observed in β-cells of islets with notable leukocyte infiltration, which has been shown to reduce insulin secretion in different mouse models [23][24][25][26]. This study speculated that the inflammatory infiltrate in the pancreas contributes to increased IL-1 production, whereas IL-1/IL-1R signaling disrupts β-cell homeostasis via the induction of NO.…”

Section: Discussionmentioning

confidence: 99%

Interleukin-1 Receptor-Induced Nitric Oxide Production in the Pancreas Controls Hyperglycemia Caused by Scorpion Envenomation

Reis

Elias-Oliveira

Pastore

et al. 2020

Toxins

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Tityus serrulatus causes numerous scorpion envenomation accidents and deaths worldwide. The symptoms vary from local to systemic manifestations, culminating in pulmonary edema and cardiogenic shock. Among these events, transitory hyperglycemia is a severe manifestation that influences pulmonary edema, hemodynamic alterations, and cardiac disturbances. However, the molecular mechanism that leads to increased glucose levels after T. serrulatus envenomation remains unknown. This study aimed to investigate our hypothesis that hyperglycemia due to scorpion envenomation involves inflammatory signaling in the pancreas. The present study showed that T. serrulatus venom induces the production of IL-1α and IL-1β in the pancreas, which signal via IL-1R and provoke nitric oxide (NO) production as well as edema in β-cells in islets. Il1r1−/− mice were protected from transitory hyperglycemia and did not present disturbances in insulin levels in the serum. These results suggest that the pathway driven by IL-1α/IL-1β-IL-1R-NO inhibits insulin release by β-cells, which increases systemic glucose concentration during severe scorpion envenomation. A supportive therapy that inhibits NO production, combined with antiserum, may help to prevent fatal outcomes of scorpion envenomation. Our findings provide novel insights into the design of supportive therapy with NO inhibitors combined with antiscorpion venom serum to overcome fatal outcomes of scorpion envenomation.

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Section: Discussionmentioning

confidence: 99%