Structural Brain Abnormalities in Patients with Parkinson Disease: A Comparative Voxel-Based Analysis Using T1-Weighted MR Imaging and Magnetization Transfer Imaging

Morgen, Katrin; Sammer, Gebhard; Weber, Lennart; Aslan, Bakiye; Müller, Christoph; Bachmann, Georg; Sandmann, Daniele; Oechsner, Matthias; Vaitl, Dieter; Kaps, Manfred; Reuter, Iris

doi:10.3174/ajnr.a2837

Cited by 29 publications

(22 citation statements)

References 29 publications

(36 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most previous studies [12–14] found that the MTR of the substantia nigra was lower in PD patients than in healthy people, and no differences were discovered in the globus pallidus, putamen or caudate. The MTR changes in the red nucleus seemed inconsistent on the basis of previous results.…”

Section: Discussionmentioning

confidence: 96%

“…The MTR changes in the red nucleus seemed inconsistent on the basis of previous results. Both Tambasco et al [12] and Anik et al [13] found a lower MTR value in PD patients, while Morgen et al [14] found no difference between PD patients and controls. However, we did not find any significant differences for the MTR(15.6 ppm) in any of the regions between normal controls and PD patients (Table 1), and this inconsistency may be due to the lower RF saturation power (2 μT) used in our protocol.…”

Section: Discussionmentioning

confidence: 99%

“…Conventional MRI does not show specific changes in PD. The use of advanced MRI techniques, such as diffusion imaging [7–9], susceptibility-weighted imaging [10, 11] and magnetization transfer imaging [12–14], may increase the accuracy of PD diagnosis. However, none of these methods have been regarded as a gold standard in the diagnosis of PD to date.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Chemical exchange saturation transfer MR imaging of Parkinson’s disease at 3 Tesla

Peng

Wang

et al. 2014

Eur Radiol

View full text Add to dashboard Cite

Objectives To demonstrate the feasibility of using chemical exchange saturation transfer (CEST) imaging to detect Parkinson’s disease (PD) in patients at 3 Tesla. Methods Twenty-seven PD patients (17 men and 10 women; age range, 54–77 years) and 22 age-matched normal controls (13 men and 9 women; age range, 55–73 years) were examined on a 3-Tesla MRI system. Magnetization transfer spectra with 31 different frequency offsets (−6 to 6 ppm) were acquired at two transverse slices of the head, including the basal ganglia and midbrain. One-way analysis of variance tests was used to compare the differences in CEST imaging signals between PD patients and normal controls. Results Total CEST signal between the offsets of 0 and 4 ppm in the substantia nigra was significantly lower in PD patients than in normal controls (P=0.006), which could be associated with the loss of dopaminergic neurons. Protein-based CEST imaging signals at the offset of 3.5 ppm in the globus pallidus, putamen and caudate were significantly increased in PD patients, compared to normal controls (P<0.001, P=0.003, P<0.001, respectively). Conclusions CEST imaging signals could potentially serve as imaging biomarkers to aid in the non-invasive molecular diagnosis of PD.

show abstract

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Chemical exchange saturation transfer MR imaging of Parkinson’s disease at 3 Tesla

Peng

Wang

et al. 2014

Eur Radiol

View full text Add to dashboard Cite

show abstract

“…PD pathology may lead to dysfunction and shrinkage of the amygdala and possibly with that the development of anxiety symptoms. There is some evidence from neuroimaging studies suggesting that amygdala volume is reduced in patients with PD compared with matched healthy controls34 35 and that (surgical) damage to the amygdala is associated with the development of anxiety 36 37. On the other hand, anxiety may itself cause of shrinkage of brain structures through overactivation of the hypothalamus-pituitary-adrenal axis (HPA) stress axis 38.…”

Section: Discussionmentioning

confidence: 99%

A smaller amygdala is associated with anxiety in Parkinson’s disease: a combined FreeSurfer—VBM study

Vriend

Boedhoe

Rutten

et al. 2015

J Neurol Neurosurg Psychiatry

View full text Add to dashboard Cite

These results confirm studies in non-PD samples showing lower left amygdalar volume in anxious patients. The results also indicate that the 'psychological' BAI subscale is a better reflection of neural correlates of anxiety in PD. Whether the left amygdalar volume decrease constitutes a premorbid trait, a PD-associated neurobiological susceptibility to anxiety or arises as a consequence of chronic anxiety symptoms remains to be determined by future prospective longitudinal studies. Nonetheless, we speculate that the Parkinson pathology is responsible for the reduction in amygdalar volume and the concomitant development of anxiety symptoms.

show abstract

“…These differences in methodologies and experimental designs may account for a substantial amount of the heterogeneity reported. Beside the brain segmentation methods, the Voxel-based analyses are also a technique used for volume estimation (Morgen et al, 2011).…”

Section: White Matter Volume Of Sensory Cortexmentioning

confidence: 99%

Structural alteration of motor and sensory cortices in Parkinson’s disease using magnetic resonance imaging: Automatic brain segmentation

Shareef¹

2018

Int. j. adv. appl. sci.

View full text Add to dashboard Cite

Parkinson's disease (PD) is a neurodegenerative disorder commonly diagnosed as motor triad of symptoms including tremor, rigidity and bradykinesia. The degeneration of the Substantia nigra in PD, leads to alterations in the function of cortical areas including primary motor cortex and other non-primary motor areas. The combination of motor and sensory symptoms marked in PD, is the cause of investigating the structural changes of motor and sensory cortices in PD. The aim of this study is to detect the structural changes of cortical thickness and the volume of grey matter and white matter in motor and sensory cortices in PD. This will help in early detection of the disease, monitor response to medication or help in prognosis and prediction of outcomes. Nineteen control volunteers and 18 Parkinson's patients were participated in the study. The ages of participants were ranging between 45-65 years (mean 56.14 years). Structural magnetic resonance imaging was performed and the Digital Imaging and Communications in Medicine (DICOM) images were evaluated using automatic brain segmentation software (BrainSuite). The structural changes in the present study were found in the thickness of the motor cortex and in the volume of grey matter (GM) of the sensory cortex. The thickness of the right motor cortex for males was smaller in Parkinson's patients than control. The volume of the GM of left sensory cortex for males was smaller in Parkinson's patients than control. While no differences were found between Patients and controls in the volume of GM or white matter (WM) in the motor cortex, or in the volume of WM and the cortical thickness in the sensory cortex. Structural changes in specific areas of the brain may influence specific symptoms.

show abstract

Structural Brain Abnormalities in Patients with Parkinson Disease: A Comparative Voxel-Based Analysis Using T1-Weighted MR Imaging and Magnetization Transfer Imaging

Cited by 29 publications

References 29 publications

Chemical exchange saturation transfer MR imaging of Parkinson’s disease at 3 Tesla

Chemical exchange saturation transfer MR imaging of Parkinson’s disease at 3 Tesla

A smaller amygdala is associated with anxiety in Parkinson’s disease: a combined FreeSurfer—VBM study

Structural alteration of motor and sensory cortices in Parkinson’s disease using magnetic resonance imaging: Automatic brain segmentation

Contact Info

Product

Resources

About