Structural Basis of the Bivalency of the TRPV1 Agonist DkTx
Venkatraman Ramanujam,
Theo Crawford,
Ben Cristofori‐Armstrong
et al.
Abstract:Bivalency is a prevalent natural mechanism to enhance receptor avidity. Various two‐domain disulfide‐rich peptides exhibiting bivalent action have been identified from animal venoms. A unique characteristic of these peptides is that they induce a pharmacological response different from that provoked by any of the constituent domains. The enhanced potency and avidity of such peptides is therefore a consequence of their domain fusion by a peptide linker. The role of the linker itself, beyond conjugation, remains… Show more
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