Cell Reports volume 3, issue 6, P1910-1920 2013 DOI: 10.1016/j.celrep.2013.04.028 View full text
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Xiaorui Chen, Fengyun Ni, Xia Tian, Elena Kondrashkina, Qinghua Wang, Jianpeng Ma

Abstract: SUMMARY Spontaneous nucleation of actin is very inefficient in cells. To overcome this barrier, cells have evolved a set of actin filament nucleators to promote rapid nucleation and polymerization in response to specific stimuli. However, the molecular mechanism of actin nucleation remains poorly understood. This is hindered largely by the fact that actin nucleus, once formed, rapidly polymerizes into filament, thus making it impossible to capture stable multisubunit actin nucleus. Here, we report an effectiv…

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