2014
DOI: 10.1038/nature13693
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Abstract: Genetic equality between males and females is established by chromosome-wide dosage-compensation mechanisms. In the fruitfly Drosophila melanogaster, the dosage-compensation complex promotes twofold hypertranscription of the single male X-chromosome and is silenced in females by inhibition of the translation of msl2, which codes for the limiting component of the dosage-compensation complex. The female-specific protein Sex-lethal (Sxl) recruits Upstream-of-N-ras (Unr) to the 3' untranslated region of msl2 messe… Show more

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Cited by 103 publications
(128 citation statements)
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“…It also reveals intermolecular cooperativity between the Sxl RRMs and the UNR CSD1 in RNA binding (Hennig et al, 2014). In this ternary complex, the Sxl RRMs bind to the 5 0 -half of the 18-mer RNA, while CSD1 interacts with the 3 0 -end of the RNA (Fig.…”
Section: Rrm-rna Interactions In the Higher Order Rnp Structuresmentioning
confidence: 94%
See 3 more Smart Citations
“…It also reveals intermolecular cooperativity between the Sxl RRMs and the UNR CSD1 in RNA binding (Hennig et al, 2014). In this ternary complex, the Sxl RRMs bind to the 5 0 -half of the 18-mer RNA, while CSD1 interacts with the 3 0 -end of the RNA (Fig.…”
Section: Rrm-rna Interactions In the Higher Order Rnp Structuresmentioning
confidence: 94%
“…Recognition of neighboring regulatory sites by trans-acting factors in a coordinated fashion, nicely illustrated by the recent ternary complex structures of Sxl RRM-UNR CSD1-RNA (Hennig et al, 2014) and ASD-1-SUP-12-RNA (Kuwasako et al, 2014), is in fact a recurrent phenomenon in eukaryotic posttranscriptional control. It is therefore clear that the interpretation of genomic data requires a certain level of precaution and it may fail to identify the exact binding position of the precipitated protein.…”
Section: Structural and Genome-wide Approachesmentioning
confidence: 96%
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“…The interaction of Sxl with poly(U) motifs has been well-characterized biochemically and structurally (Inoue et al 1990;Valcárcel et al 1993;Handa et al 1999;Hennig et al 2014). In addition to its interaction with msl-2 mRNA (Bashaw and Baker 1995;Kelley et al 1995Kelley et al , 1997Bashaw and Baker 1997), Sxl also binds to poly(U) motifs present in its own mRNA (Cline 1984;Bell et al 1991) and in the transformer mRNA (tra) (Boggs et al, 1987).…”
Section: Specific Rnp Capture In Vitromentioning
confidence: 99%