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Cited by 30 publications
(58 citation statements)
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“…Our strategy took advantage of previous structure-based drug design (SBDD) studies that revealed essential requirements for SmPNP binding affinity and selectivity (e.g., binding to the hydrophobic pocket near Phe161, H-bonding to Tyr201). 10 The results reported herein revealed important molecular requirements for the design of new PNP inhibitors with improved potency.…”
Section: Introductionmentioning
confidence: 81%
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“…Our strategy took advantage of previous structure-based drug design (SBDD) studies that revealed essential requirements for SmPNP binding affinity and selectivity (e.g., binding to the hydrophobic pocket near Phe161, H-bonding to Tyr201). 10 The results reported herein revealed important molecular requirements for the design of new PNP inhibitors with improved potency.…”
Section: Introductionmentioning
confidence: 81%
“…Kinetic measurements were carried out spectrophotometrically with the aid of a Cary100 UV-Vis spectrophotometer, using a standard coupled assay as previously described. 10,[13][14][15][16] The reaction mixture contained 5 nmol L -1 SmPNP (as the monomer), 50 mmol L -1 phosphate buffer (K 3 PO 4 , pH 7.4), 10 µmol L -1 inosine, and xanthine oxidase 40 milliunits mL -1 . Uric acid formation was monitored at 293 nm, in triplicate at 25 o C (extinction coefficient for uric acid, e 293 = 12.9 L mmol -1 cm -1 ).…”
Section: Biochemical Assays and Data Set Compositionmentioning
confidence: 99%
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