Abstract:S. pneumoniae is the leading cause of community-acquired infections worldwide. Its global success might in part be explained by its genetic transformation, which consists of the internalization and the incorporation in the bacterial chromosome of exogenous DNA. Transformation is turned on in cells which are in a physiological state called competence. The induction of the competent state depends on the two-component regulatory system ComD-ComE. The response regulator (RR) ComE is phosphorylated by the histidine… Show more
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