Structural and functional characteristics of the LMP1 oncogene in patients with tumors аssociated and not associated with the Epstein–Barr virus

The purpose of this article is to review and analyze the foreign and domestic scientific papers to assess the Epstein-Barr virus (EBV) occurrence in the human population. A search of Russian and foreign publications in the PubMed and E-library databases was conducted. The high ecological and medical significance of EBV-infection is due to its global spread in the human population, lifelong persistence of EBV in the human body. Evidence has been collected EBV to be involved in the development of various somatic pathologies, such as rheumatic diseases and vasculitis, chronic kidney disease, cardiovascular pathologies, pathologies of the gastrointestinal tract, T- and B-cell lymphomas in children and adults, nasopharyngeal carcinoma. These diseases are the main causes of population disability and premature death not only in Russia, but also in the World. The deterioration of the ecological and epidemic situation for EBV-infection is associated with the other infectants spread that change the population immunological status. These include the human immunodeficiency virus, hepatitis B and C viruses, SARS-CoV-2, Mycobacterium tuberculosis. With the simultaneous persistence of these infectants, their synergistic or antagonistic effect on the human body occurs. In the modern World, the COVID-19 and the EBV-infection are simultaneously developing. It is difficult to say which infection is more significant in terms of medical, social. and economic losses of the human population. The EBV has been undeservedly given little attention. It is necessary to optimize preventive measures and epidemic surveillance for EBV-infection.

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Structural and functional characteristics of the LMP1 oncogene in patients with tumors аssociated and not associated with the Epstein–Barr virus

Cited by 2 publications

References 32 publications

Epstein–Barr Virus: Evaluation of gp350 and EBNA2 Gene Variability

Epstein–Barr Virus: Evaluation of gp350 and EBNA2 Gene Variability

Evaluation of the Epstein–Barr virus occurrence at the present stage (literature review)

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