Structural and functional alterations of the heart in Parkinson’s disease

Piqueras‐Flores, Jesús; López-García, Ana; Moreno-Reig, Álvaro; González-Martínez, Alicia; Hernández-González, Amalia; Vaamonde-Gamo, Julia; Jurado-Román, Alfonso

doi:10.1080/01616412.2017.1390933

Cited by 35 publications

(44 citation statements)

References 47 publications

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“…PD patients die from different causes including aspiration pneumonia, dementia, old age, cancer, cardiovascular disease and sudden unexpected death 21–23 . Several studies have shown that changes in cardiac function may be present in PD patients 12,24 . Scorza et al .…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular alterations in rats with Parkinsonism induced by 6-OHDA and treated with Domperidone

Rodrigues

Oliveira

Shinoda

et al. 2019

Sci Rep

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After Alzheimer, Parkinson disease (PD) is the most frequently occurring progressive, degenerative neurological disease. It affects both sympathetic and parasympathetic nervous systems in a variable fashion. Cardiovascular symptoms are present in almost all stages of PD and narrower heart rate variability is the earliest sign. Administration of Levodopa to PD patients has proven to provide some degree of neurological protection. This drug, however, causes side effects including nausea and vomiting, lessened by the administration of domperidone. Autopsies in PD patients led some researchers to suggest the involvement of the ventricular arrhythmia induced by domperidone. The aim of the present study was to determine the impact of the adjusted human maximal dose of domperidone, on cardiological features of Wistar rats. domperidone was administered to both 6-hydroxydopamine Parkinsonism models and regular Wistar rats. Quantitative analysis of ranges of heart beat variation showed significant abnormal distribution in both groups receiving domperidone as compared with respective sham counterparts. However, qualitative analysis of Poincaré plots showed that 6-hydroxydopamine Parkinsonism models receiving domperidone had the narrowest full range of heart beat and the worst distribution heart beat ranges as compared with all study groups corroborating with previous suggestion that domperidone administration to PD patients is likely to play a role in sudden unexpected death in this group of patients.

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Section: Discussionmentioning

confidence: 99%

Cardiovascular alterations in rats with Parkinsonism induced by 6-OHDA and treated with Domperidone

Rodrigues

Oliveira

Shinoda

et al. 2019

Sci Rep

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show abstract

“…Cardiac dysautonomia and sympathetic nervous system impairments of the heart have been reported in neurodegenerative diseases (Goldstein 2014, Joers & Emborg 2014, Piqueras-Flores et al 2017. MPTP toxicity studies in mice have suggested a selective vulnerability of monoamine cells.…”

Section: Discussionmentioning

confidence: 99%

The effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mice myocardial morphology

Sasahara

Machado

2019

Pesq. Vet. Bras.

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Studies have demonstrated sympathetic cardiac denervation in the MPTP mouse model. MPTP toxicity causes sympathetic nerve damage and depletion of heart norepinephrine. Previous evaluations of impairments in heart innervation have been based on imaging, electrophysiological and biochemical methods. However, these studies lacked information that can be obtained from morphoquantitative analyses. Thus, this study aimed to apply a design-based stereological method for evaluating the morphoquantitative alterations of myocardium following treatment with the neurotoxin MPTP in the C57/BL mouse. Our results showed that MPTP reduced the number of cardiomyocytes in the left ventricle.

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“…The prevalence of heart failure has been found to be twice as high among PD patients compared with overall population regardless of any other heart or cardiovascular disease risk factors [65]. PD is significantly associated with increased concentric left ventricular hypertrophy and diastolic dysfunction, and advanced stages of PD are associated with a more severe cardiac affection [66], which may explain the higher prevalence of heart failure in PD patients. As a mouse model of PD, PINK1 KO mice also showed left ventricular dysfunction and cardiac hypertrophy [67].…”

Section: Discussionmentioning

confidence: 99%