2001
DOI: 10.1128/mcb.21.21.7117-7136.2001
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Abstract: With the current access to the whole genomes of various organisms and the completion of the first draft of the human genome, there is a strong need for a structure-function classification of protein families as an initial step in moving from DNA databases to a comprehensive understanding of human biology. As a result of the explosion in nucleic acid sequence information and the concurrent development of methods for high-throughput functional characterization of gene products, the genomic revolution also promis… Show more

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Cited by 645 publications
(695 citation statements)
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References 103 publications
(129 reference statements)
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“…Threonine-507 (T507) of SHP-2 is highly conserved among PTPs (Andersen et al, 2001) and constitutes the surface of the catalytic cleft in the PTP domain, facing the N-SH2 domain in the basal state of SHP-2 (Hof et al, 1998) (Figures 1c and d). The lysine substitution may inhibit the autoinhibitory interaction between the N-SH2 domain and PTP domain, thereby activating the basal phosphatase activity.…”
Section: Resultsmentioning
confidence: 99%
“…Threonine-507 (T507) of SHP-2 is highly conserved among PTPs (Andersen et al, 2001) and constitutes the surface of the catalytic cleft in the PTP domain, facing the N-SH2 domain in the basal state of SHP-2 (Hof et al, 1998) (Figures 1c and d). The lysine substitution may inhibit the autoinhibitory interaction between the N-SH2 domain and PTP domain, thereby activating the basal phosphatase activity.…”
Section: Resultsmentioning
confidence: 99%
“…Alignment of other target PTPs not described in this review may be generated using any standard web-based alignment application (ClustalW, NCBI's Blast 2 Sequences, etc.). Alternatively, Andersen et al's very helpful alignment of all human PTP domains may be consulted [2].…”
Section: Identification Of V49 and I219 Analogs In Other Ptpsmentioning
confidence: 99%
“…The protein tyrosine phosphatases (PTPs), an enzyme superfamily that includes about 100 human proteins, catalyze the dephosphorylation of phosphotyrosine in protein substrates [1][2][3]. Phosphotyrosine is a critical cell-signaling control element, and PTP activity is essential both for cellular homeostasis and for appropriate responses to extracellular signals.…”
Section: Introductionmentioning
confidence: 99%
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