Structural and electrochemical studies of functionalization of reduced graphene oxide with alkoxyphenylporphyrin mono- and tetra- carboxylic acid: application to DNA sensors

Abstract

Association of graphene with conjugated organic macromolecules presents an interest in various applications. Here, we study the chemical and electrical properties of nanomaterials which combine the features of chemical reduced graphene oxide (CRGO) and its modification with tetrabutyloxyphenylporphyrins bearing a mono-or tetra-carboxylic functions. The hybrid nanomaterials are characterized through different techniques including UV-visible, FT-IR, Raman spectroscopy, MEB and SEM. Their electrochemical properties are studied by cyclic voltammetry (CV) with inner sphere and outer sphere redox markers as well as electrochemical impedance spectroscopy (EIS). The overall results support the formation of strong interactions between porphyrins and CRGO. Furthermore, we highlight the relationship of structural and electronic properties of porphyrins on the resulted composite. Thus, we demonstrate that modified porphyrins with alkoxy and carboxyl groups improve the dispersion of CRGO and have positive effects on their electronic properties in particular the electron transfer ability. These nanocomposites open new opportunities for their application in biosensors devices and the detection of DNA of M. Tuberculosis was demonstrated with LOD at attomolar range and an ability to discrimination of M. tuberculosis strand from mutated in PCR sample.

Graphene quantum dot-porphyrin/phthalocyanine multifunctional hybrid systems: from interfacial dialogue to application

“…Measurements using several independent biosensors were used to assess the reproducibility of this DNA hybridization platform. 221 Various studies using rGO-porphyrin and GQD-Pp composite have been reported for the electrochemical sensing of serotonin, dopamine, and glucose sensing, demonstrating enhanced selectivity and sensitivity towards these analytes. 222,223 Zhang et al developed a "turn-ON" fluorescence sensor via optical sensing for the detection of hydrogen peroxide (H 2 O 2 ) and glucose using a GQD/FeTMPyP hybrid system (Fig.…”

Recent Advances in Chemical Sensors Using Porphyrin-Carbon Nanostructure Hybrid Materials

“…A nanocomposite material consisting of CrGO and tetraphenylporphyrin derivatives, bearing one or four butyloxyphenyl groups, was prepared and fully characterized by Korri-Youssoufi's group [34]. The presence of these peripheral groups on the porphyrin skeleton improved both the dispersibility and the electron transfer ability.…”

Design of novel sensitive terahertz metamaterial absorbers based on graphene-plasmonic nanostructures

“…where c, L and C are speed of the light in vacuum, capacitance and inductance, respectively. Enhancing Ef1 would diminish the inductance value L [25], which would decrease the absorption peak wavelength according to (6). Considering Ef1=0.9ev, the short wavelength ranges of 30-45µm with 97% absorption peak and long wavelength ranges of 45-60µm with 94% peak, would be achieved.…”

“…Indeed, SPR-refractive index (SPR-RI) biosensors have attracted extreme attentions [2]. Biosensors can be utilized as diagnosis instruments, clinical and lab detection devices [3,4], and also for sensing various bio-molecules such as proteins [5], DNA [6] and other vital tissues. SPR based sensors have interesting and appropriated specifications that make them good candidates for bio-sensing applications.…”