Structural and biological engineering of 3D hydrogels for wound healing

Norahan, Mohammad Hadi; Pedroza-González, Sara Cristina; Sánchez-Salazar, Mónica Gabriela; Álvarez, Mario Moisés; Santiago, Grissel Trujillo‐de

doi:10.1016/j.bioactmat.2022.11.019

Cited by 99 publications

(78 citation statements)

References 231 publications

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“…When it comes to in situ gelation properties, it is important to mention photocrosslinked hydrogels. [77][78][79] It is well known that natural ECMs have to be turned into ECM gels by enzymatic digestion, pH neutralization, ionic equilibrium, and temperature regulation. The rate of gel formation is not very fast and cannot be improved by adjusting pH, salt ion concentration, etc.…”

Section: Chemical Modificationmentioning

confidence: 99%

The engineering and application of extracellular matrix hydrogels: a review

Zhang

2023

Biomater. Sci.

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Section: Chemical Modificationmentioning

confidence: 99%

The engineering and application of extracellular matrix hydrogels: a review

Zhang

2023

Biomater. Sci.

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“…Chemical crosslinking results from covalent bonds that form through chemical reactions, and since covalent interactions are much stronger than the noncovalent interactions, chemically crosslinked hydrogels have better mechanical stability [ 110 – 112 ]. Compared with traditional wound dressings, hydrogels keep wounds moist and continuously absorb exudate, and some hydrogels prepared from chitosan and alginate can degrade over time to avoid secondary damage during dressing changes [ 24 ]. More importantly, scientists can endow hydrogel dressings with a variety of excellent properties through structural design and functional integration, which play important roles in the DU healing process.…”

Section: Advanced Polymer Hydrogels For Dusmentioning

confidence: 99%

“…Moreover, the existence of a porous network structure provides a good environment for gas exchange and nutrient transport. Third, due to their unique structural properties, hydrogels do not cause secondary mechanical damage [ 24 ]. The granulation tissue in wounds has a propensity to grow into traditional dry dressings in the form of a mesh, tending to adhere to the dressing when it is being changed and cause secondary mechanical damage.…”

Section: Introductionmentioning

confidence: 99%

Advanced polymer hydrogels that promote diabetic ulcer healing: mechanisms, classifications, and medical applications

Wei

et al. 2023

Biomater Res

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Diabetic ulcers (DUs) are one of the most serious complications of diabetes mellitus. The application of a functional dressing is a crucial step in DU treatment and is associated with the patient's recovery and prognosis. However, traditional dressings with a simple structure and a single function cannot meet clinical requirements. Therefore, researchers have turned their attention to advanced polymer dressings and hydrogels to solve the therapeutic bottleneck of DU treatment. Hydrogels are a class of gels with a three-dimensional network structure that have good moisturizing properties and permeability and promote autolytic debridement and material exchange. Moreover, hydrogels mimic the natural environment of the extracellular matrix, providing suitable surroundings for cell proliferation. Thus, hydrogels with different mechanical strengths and biological properties have been extensively explored as DU dressing platforms. In this review, we define different types of hydrogels and elaborate the mechanisms by which they repair DUs. Moreover, we summarize the pathological process of DUs and review various additives used for their treatment. Finally, we examine the limitations and obstacles that exist in the development of the clinically relevant applications of these appealing technologies. Graphical Abstract This review defines different types of hydrogels and carefully elaborate the mechanisms by which they repair diabetic ulcers (DUs), summarizes the pathological process of DUs, and reviews various bioactivators used for their treatment.

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“…Other factors such as degradability and water retention capability are also necessary to be optimized. The structural properties of the hydrogel are influenced by the type of polymer (natural, synthetic, or semisynthetic) used, the cross-linking method, the concentration of the polymer, and the fabrication method . This review provides an outlook regarding the hydrogels’ current research status as wound dressings and highlights the types of hydrogels, cross-linking techniques, and novel hydrogel structures.…”

Section: Introductionmentioning

confidence: 99%

“…The structural properties of the hydrogel are influenced by the type of polymer (natural, synthetic, or semisynthetic) used, the cross-linking method, the concentration of the polymer, and the fabrication method. 12 This review provides an outlook regarding the hydrogels' current research status as wound dressings and highlights the types of hydrogels, cross-linking techniques, and novel hydrogel structures. It provides brief information on novel hydrogelbased approaches investigated for the treatment of chronic wounds.…”

Section: Introductionmentioning

confidence: 99%

Design Considerations, Formulation Approaches, and Strategic Advances of Hydrogel Dressings for Chronic Wound Management

2023

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Wound healing is a complex and dynamic physiological process consisting of a series of cellular and molecular events that initiate immediately after a tissue lesion, to reconstruct the skin layer. It is indubitable that patients with chronic wounds, severely infected wounds, or any metabolic disorder of the wound microenvironment always endure severe pain and discomfort that affect their quality of life. It is essential to treat chronic wounds for conserving the physical as well as mental well-being of affected patients and for convalescing to improve their quality of life. For supporting and augmenting the healing process, the selection of pertinent wound dressing is essential. A substantial reduction in healing duration, disability, associated cost, and risk of recurrent infections can be achieved via engineering wound dressings. Hydrogels play a leading role in the path of engineering ideal wound dressings. Hydrogels, comprising water to a large extent, providing a moist environment, being comfortable to patients, and having biocompatible and biodegradable properties, have found their success as suitable wound dressings in the market. The exploitation of hydrogels is increasing perpetually after substantiation of their broader therapeutic actions owing to their resemblance to dermal tissues, their capability to stimulate partial skin regeneration, and their ability to incorporate therapeutic moieties promoting wound healing. This review entails properties of hydrogel supporting wound healing, types of hydrogels, cross-linking mechanisms, design considerations, and formulation strategies of hydrogel engineering. Various categories of hydrogel wound dressing fabricated recently are discussed based on their gel network composition, degradability, and physical and chemical cross-linking mechanisms, which provide an outlook regarding the importance of tailoring the physicochemical properties of hydrogels. The examples of marketed hydrogel wound dressings are also incorporated along with the future perspectives and challenges associated with them.

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Structural and biological engineering of 3D hydrogels for wound healing

Cited by 99 publications

References 231 publications

The engineering and application of extracellular matrix hydrogels: a review

The engineering and application of extracellular matrix hydrogels: a review

Advanced polymer hydrogels that promote diabetic ulcer healing: mechanisms, classifications, and medical applications

Design Considerations, Formulation Approaches, and Strategic Advances of Hydrogel Dressings for Chronic Wound Management

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